Metagenomic Analysis of Gut Microbiome in Korean Patients With Ulcerative Colitis
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT01010815 |
Recruitment Status
: Unknown
Verified November 2009 by Seoul National University Hospital.
Recruitment status was: Recruiting
First Posted
: November 10, 2009
Last Update Posted
: November 10, 2009
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Condition or disease | Intervention/treatment |
---|---|
Ulcerative Colitis | Procedure: Colonoscopy biopsy Other: stool collection Procedure: colonoscopy biopsy |
Study Type : | Observational |
Estimated Enrollment : | 15 participants |
Observational Model: | Case Control |
Time Perspective: | Prospective |
Official Title: | Metagenomic Analysis of Gut Microbiome in Korean Patients With Ulcerative Colitis |
Study Start Date : | November 2009 |
Estimated Primary Completion Date : | November 2010 |
Estimated Study Completion Date : | November 2011 |

Group/Cohort | Intervention/treatment |
---|---|
UC group
clinically and microscopically confirmed UC patients between the age of 19 and 75 years
|
Procedure: colonoscopy biopsy
colonoscopy biopsy will be conducted in rectum, ascending and descending colon from participants 2 times during study - at active phase and inactive phase
Other: stool collection
stool will be collected from participants 2 times during study - at active phase and inactive phase
|
Control group
normal healthy controls
|
Procedure: Colonoscopy biopsy
Colonoscopy biopsy will be performed in rectum, ascending and descending colon at study entry
Other: stool collection
Stool will be collected from participants at study entry
|
- characterize the difference in gut microbiomes through metagenomic analysis between UC patients and normal control subjects [ Time Frame: 1 year ]
- characterize the difference in gut microbiomes through metagenomic analysis between stool specimens and biopsy specimens in participants with UC and normal subjects [ Time Frame: 1 year ]
- characterize the difference in gut microbiomes among colonoscopy biopsy locations (rectum, ascending and descending colon) [ Time Frame: 1 year ]
- characterize the difference in gut microbiomes between active and inactive UC patients [ Time Frame: 1 year ]
Biospecimen Retention: Samples With DNA

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 19 Years to 75 Years (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Between the age of 19 and 75 years
- willing to consent/undergo necessary procedures
- clinically active or inactive Ulcerative colitis
Exclusion Criteria:
- Inability to provide informed consent or
- Clinically severe or fulminant ulcerative colitis
- Previous abdominal surgery
- Pregnancy
- Clinically or laboratory-confirmed gastroenteritis for at least 3 months before sampling
- the use of antibiotics in the past a month before sampling
- the use of probiotics in the past a month before sampling
- Severe cardiovascular or pulmonary disease
- Severe convulsive disorder and current use of anti-convulsive medication
- Malignancy
- Transplantation

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01010815
Contact: Joo Sung Kim, M.D., PhD | +82-2-740-8112 | jooskim@snu.ac.kr | |
Contact: Seong-Joon Koh, M.D. | +82-2-740-8112 | jel1206@medimail.co.kr |
Korea, Republic of | |
Seoul National University Hospital | Recruiting |
Seoul, Korea, Republic of, 110-744 | |
Contact: Joo Sung Kim, Ph.D 82-2-740-8112 jooskim@snu.ac.kr | |
Contact: Seong-Joon Koh 82-2-740-8112 jel1206@medimail.co.kr |
Principal Investigator: | Joo Sung Kim, M.D., PhD | Seoul National University Hospital |
Responsible Party: | Joo Sung Kim, Seoul National University Hospital |
ClinicalTrials.gov Identifier: | NCT01010815 History of Changes |
Other Study ID Numbers: |
Gut Microbiome in UC Patients |
First Posted: | November 10, 2009 Key Record Dates |
Last Update Posted: | November 10, 2009 |
Last Verified: | November 2009 |
Keywords provided by Seoul National University Hospital:
ulcerative colitis gut microbiome metagenomics |
Additional relevant MeSH terms:
Colitis Ulcer Colitis, Ulcerative Gastroenteritis Gastrointestinal Diseases |
Digestive System Diseases Colonic Diseases Intestinal Diseases Pathologic Processes Inflammatory Bowel Diseases |