Quantification of Cerebral Cholinergic Function in Parkinson´s Disease by Means of Nuclear Medicine Methods
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|ClinicalTrials.gov Identifier: NCT01003535|
Recruitment Status : Completed
First Posted : October 28, 2009
Last Update Posted : July 4, 2012
Parkinson´s disease is based on a Lewy body degeneration of cerebral and extracerebral neurons. This Lewy body degeneration includes cerebral cholinergic neurons besides dopaminergic neurons.
In previous studies the investigators found that some clinical parkinsonian symptoms - primarily hypokinesia and rigidity - significantly correlate with the dopaminergic nigrostriatal degeneration which was quantified by dopamine transporter imaging. In contrast to that, resting or postural parkinsonian tremor does not correlate with the dopaminergic nigrostriatal degeneration. Obviously further cerebral changes - for instance possible changes / degeneration of cerebral cholinergic neurons - contribute to parkinsonian tremor.
In this study the investigators apply cerebral 5-IA-85380-SPECT to quantify the local density of cerebral nicotinergic cholinergic receptors in patients with Parkinson´s disease. The investigators will correlate the results of cerebral 5-IA-85380-SPECT with the clinical parkinsonian main symptoms hypokinesia, rigidity and primarily resting and postural tremor. In particular, it is of interest whether changes of cerebral cholinergic neurons are involved in the generation of parkinsonian tremor.
|Condition or disease|
|Parkinson´s Disease Acetylcholine SPECT|
|Study Type :||Observational|
|Actual Enrollment :||25 participants|
|Official Title:||Quantification of Cerebral Cholinergic Function in Patients With Parkinson´s Disease by Means of Nuclear Medicine Methods|
|Study Start Date :||January 2010|
|Actual Primary Completion Date :||April 2012|
|Actual Study Completion Date :||April 2012|
- Correlation of density of acetylcholine receptors in distinct brain areas versus the clinical parameters resting tremor, postural tremor, hypokinesia and rigidity in patients with Parkinson´s disease [ Time Frame: 1 time ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01003535
|Department of Neurology, Saarland University|
|Homburg/Saar, Saarland, Germany, D-66421|
|Principal Investigator:||Joerg Spiegel, M.D.||Department of Neurology, Saarland University, Kirrberger Strasse, D-66421 Homburg/Saar, Germany|