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Effects of Different Mode of Exercise Training on Type 2 Diabetes

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01000519
Recruitment Status : Completed
First Posted : October 23, 2009
Last Update Posted : February 10, 2017
Information provided by (Responsible Party):
Singapore General Hospital

Brief Summary:
Randomized study on the comparison between aerobic training versus progressive resistance training over a 2 months period for older adults with type 2 diabetes. The hypothesis is that progressive resistance training is just as effective as aerobic training on Hba1c and could be an alternative training for those older diabetic patients who cannot participate in aerobic exercise.

Condition or disease Intervention/treatment Phase
Diabetes Mellitus, Type 2 Other: Aerobic Training Other: Progressive resistance training Not Applicable

Detailed Description:

Many studies have shown the importance of aerobic training with respect to management of diabetes. However adoption of aerobic activities may be challenging for some individuals with diabetes, especially the elderly and the obese. There is increasing interest in resistance training and no study have looked at direct comparison between the two.

Subjects with diabetes but is generally sedentary (determined by means of a questionnaire) were recruited and randomized in one of the two groups. Subjects are supervised in a group and a completer is defined as one who completed 18 sessions within 8 weeks.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Differential Effects of Aerobic Versus Progressive Resistance Training on Metabolic Profile and Fitness in Older Adults With Diabetes Mellitus - a Randomized Controlled Trial
Study Start Date : December 2002
Actual Primary Completion Date : June 2006
Actual Study Completion Date : June 2006

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Active Comparator: Aerobic Training
50 minutes of aerobic training, 18 sessions within 2 months period
Other: Aerobic Training
18 sessions over 2 months period. Each session consist of 50 minutes of aerobic training at 65-70 % of maximum predicted heart rate
Other Names:
  • Treadmill
  • Cross trainer
  • Cycling

Experimental: Progressive Resistance Training
50 minutes of progressive resistance training consisting of nine resistance exercises, each conducted 3 sets of 10 repetitions. 18 sessions over 2 months period.
Other: Progressive resistance training
18 sessions completed in 2 months. each session consists of 50 minutes of resistance training which is made up of 3 sets of 10 repetitions of nine resistive exercises using machines and free weights at 65-70% of 1-repetitive maximum.
Other Names:
  • Weight training
  • Circuit training

Primary Outcome Measures :
  1. Hemoglobin A, Glycosylated (Hba1c). Measuring unit: percentage [ Time Frame: 2 months ]
    Blood was drawn from each subject who fasted at least 10 hours overnight. Hba1c (%) was measured using high performance liquid chromatography (HPLC Variant II Bio Rad Laboratories, Munich, Germany). Change in Hba1c before and after intervention were looked at.

Secondary Outcome Measures :
  1. Peak volume of oxygen consumed (VO2peak) or fitness level. Measuring unit: ml/kg/min [ Time Frame: 2 months ]
    Modified Bruce protocol on a treadmill using Cosmed K4B2 machine to measure

  2. Anthropometric measurements [ Time Frame: 2 months ]
    weight (kilogram), height (metres), body mass index (BMI), waist circumference (centimeters) and body fat (percentage). Measurements to be taken before and after intervention.

  3. Cholesterol [ Time Frame: 2 months ]
    Blood was drawn from each subject who fasted at least 10 hours overnight. Total cholesterol and triglycerides (TG) were measured using enzymatic colorimetric methods with cholesterol oxidase-peroxidase amino phenazone phenol and glycerol-3-phospahte oxidase-peroxidase amino phenazone phenol. High-density lipoprotein cholesterol (HDL-C) was measured using homogenous enzymatic colorimetric assay. Low-density lipoprotein cholesterol (LDL-C) was calculated using the Friedewald formula.

Information from the National Library of Medicine

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Ages Eligible for Study:   50 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • aged 50 years and above,
  • Hba1c between 8 to 10 % in the past one month,
  • sedentary,
  • able to continuously walk for at least 20 minutes and climbed one flight of stairs unaided without stopping were eligible for participation.

Exclusion Criteria:

  • uncontrolled diabetes mellitus with Hba1c more than 10% or if escalation of treatment of glycemic control or dyslipidemia was likely to be necessary over the 2 months training period period,
  • congestive cardiac failure, unstable angina or acute myocardial infarction within the last one year,
  • proliferative diabetic retinopathy,
  • uncontrolled hypertension,
  • advanced arthritis likely to limit mobility or participation in prescribed exercises,
  • respiratory conditions such as asthma and chronic obstructive lung disease,
  • significant proteinuria or chronic renal insufficiency,
  • received drugs for the treatment of obesity or very low caloric diet (VLCD, less than 1000 kcal/ day),
  • renal disease and
  • inability to monitor glucose level or comply with exercise program.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01000519

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Singapore General Hospital
Singapore, Singapore, 169608
Sponsors and Collaborators
Singapore General Hospital
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Principal Investigator: Li Whye Cindy Ng Singapore General Hospital
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Singapore General Hospital Identifier: NCT01000519    
Other Study ID Numbers: NMRC/0728/2003
First Posted: October 23, 2009    Key Record Dates
Last Update Posted: February 10, 2017
Last Verified: February 2017
Keywords provided by Singapore General Hospital:
Diabetes mellitus
Randomized control trial
Hemoglobin A, Glycosylated
Additional relevant MeSH terms:
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Diabetes Mellitus
Diabetes Mellitus, Type 2
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases