Collagen Analysis and Genetic Analysis of Families With Tendency to Hernias
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ClinicalTrials.gov Identifier: NCT00991484 |
Recruitment Status
: Unknown
Verified October 2010 by Herlev Hospital.
Recruitment status was: Recruiting
First Posted
: October 8, 2009
Last Update Posted
: October 13, 2010
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Condition or disease |
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Hernia |
Research has shown relationship between hernias and collagen subtype I/III ratio, biomarkers such as MMP's TIMP's and other diseases such as Ehlers-Danlos, Marfans syndrome, AAA (abdominal aortic aneurysms), diverticulosis and rectal prolapse. Furthermore has research raised hypothesis about inheritance of hernias. The investigators are performing genetic examination combined with analysis of collagen and biomarkers on patients belonging to families with tendency to hernias.
Other examinations performed on the patients enrolled in this study:
- Ultrasound (US) examination of the abdominal aorta to discover possible abdominal aortic aneurysms.
- Beightons score to evaluate the degree of joint hypermobility.
Study Type : | Observational |
Estimated Enrollment : | 60 participants |
Observational Model: | Family-Based |
Time Perspective: | Prospective |
Official Title: | Collagen-subtype Analysis in Subcutaneous Tissue and Genetic Analysis on Patients From Families With a Tendency to Hernias |
Study Start Date : | December 2009 |
Estimated Primary Completion Date : | December 2010 |
Estimated Study Completion Date : | June 2011 |
Group/Cohort |
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control group |
individuals from hernia-family |
- Expression of collagen-genes or other relevant genes by microarray analysis compared with presence of hernia [ Time Frame: 1 year ]
- Amount of collagen subtypes measured subcutaneously. [ Time Frame: 1 year ]
Biospecimen Retention: Samples With DNA

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Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- adults over 18 years
- adults must be members of a family where there are presence of hernias in minimum generation.
Exclusion Criteria:
- infections
- pregnant
- mentally ill patients

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00991484
Contact: Jakob Burcharth, MD | 0045 44884488 ext 89434 | jakobburcharth@gmail.com |
Denmark | |
Herlev Hospital | Recruiting |
DK-2730, Herlev, Herlev, Denmark, 2730 | |
Contact: jakob Burcharth, MS 004544884488 jakobburcharth@gmail.com | |
Principal Investigator: Jakob Burcharth, MD |
Study Director: | Jacob Rosenberg, Prof. MD | Herlev Hospital | |
Principal Investigator: | Jakob Burcharth, MD | Herlev Hospital |
Responsible Party: | Jakob Burcharth, MD., Herlev Hospital, Department of surgical Gastroenterology |
ClinicalTrials.gov Identifier: | NCT00991484 History of Changes |
Other Study ID Numbers: |
H-4-2009-123 |
First Posted: | October 8, 2009 Key Record Dates |
Last Update Posted: | October 13, 2010 |
Last Verified: | October 2010 |
Keywords provided by Herlev Hospital:
ventral inguinal hernia inheritance genetics |
Additional relevant MeSH terms:
Hernia Pathological Conditions, Anatomical |