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Effect of Succinylcholine on Patients Using Statins

This study has been completed.
Information provided by (Responsible Party):
Alparslan Turan, The Cleveland Clinic Identifier:
First received: September 23, 2009
Last updated: August 24, 2016
Last verified: August 2016
Based on available mechanistic and clinical information, the investigators propose a nonrandomized study to evaluate the effect of succinylcholine in patients taking statins. The investigators' purpose is to evaluate the effect of succinylcholine on patients taking statins. Patients scheduled to undergo elective surgery (other then orthopedic, spinal, vascular or muscle) with planned endotracheal intubation will be approached regarding participation in the trial. Design of the study is complex because there is no way to randomize patients to statins or no statins and also no way to take them off the statins prior surgery. So statin use will not be randomized; confounding factors will be accounted for by stratification (every 10 years of age from 40-80 and gender) and statistical adjustment. The investigators propose to test the hypothesis that succinylcholine administration increases plasma myoglobin concentration more in patients who are on statins compared to patients who do not.

Condition Intervention
Drug: Succinylcholine

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Effect of Succinylcholine on Patients Using Statins

Resource links provided by NLM:

Further study details as provided by Alparslan Turan, The Cleveland Clinic:

Primary Outcome Measures:
  • Plasma Myoglobin Concentration [ Time Frame: induction, 5 minutes after administration, 20 minutes and 24 hours post operatively ]

Secondary Outcome Measures:
  • Muscle Pain [ Time Frame: 2 and 24 hours postoperatively ]

    verbal rating scale score and the pain score both at 2 and 24 hours postoperatively.

    The verbal rating scale score ranges from 0 (no pain) to 100 (worst pain imaginable).

    The pain score ranges from 0 to 3: 0 none; 1 muscle stiffness or pain in the nape of the neck, shoulders, and chest; 2 muscle stiffness and pain requiring analgesia; and 3 incapacitating generalized muscle stiffness or pain.

  • Serum Potassium Concentration [ Time Frame: At 5 and 20 min after succinylcholine ]
  • Change in Plasma Creatine Phosphokinase (CK) Concentration From 2 to 24 Hours Postoperatively [ Time Frame: 2 and 24 hours postoperatively ]
    Change in plasma creatine phosphokinase (CK) concentration from 2 to 24 hours postoperatively

  • Duration of Succinylcholine Block [ Time Frame: intraoperative: from succinylcholine administration ]
    Time required to reach maximum block by succinylcholine after succinylcholine administration.

  • Fasciculation [ Time Frame: postoperative ]
    The fasciculation ranges from 0 to 3: 0 none; 1 small movements around eyes and fingers; 2 moderate movements in face, neck, fingers, and trunk; and 3 vigorous movements in trunk and extremities.

Enrollment: 70
Study Start Date: September 2009
Study Completion Date: July 2010
Primary Completion Date: July 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Statin use group
Patients taking simvastatin, lovastatin, atorvastatin, or pravastatin for at least three months.
Drug: Succinylcholine
Succinylcholine will be administered pre-induction over a period of 5 seconds
non statin use
Patients not taking simvastatin, lovastatin, atorvastatin, or pravastatin for at least three months.
Drug: Succinylcholine
Succinylcholine will be administered pre-induction over a period of 5 seconds


Ages Eligible for Study:   40 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Scheduled for elective surgery not involving orthopedic procedure, muscle and spinal surgery
  • ASA Physical Status 1-3

Exclusion Criteria:

  • History of liver failure
  • History of renal failure
  • History of neuromuscular disease
  • Increased intraocular pressure
  • Recent major burn
  • Multiple trauma
  • Susceptibility to or family history of malignant hyperthermia
  Contacts and Locations
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Please refer to this study by its identifier: NCT00986583

United States, Ohio
Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195
Sponsors and Collaborators
The Cleveland Clinic
Principal Investigator: Alparsan Turan, MD The Cleveland Clinic
  More Information

Responsible Party: Alparslan Turan, Principal Investigator, The Cleveland Clinic Identifier: NCT00986583     History of Changes
Other Study ID Numbers: 09-683
Study First Received: September 23, 2009
Results First Received: December 24, 2015
Last Updated: August 24, 2016

Keywords provided by Alparslan Turan, The Cleveland Clinic:
statins with succinylcholine and pain

Additional relevant MeSH terms:
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Neuromuscular Depolarizing Agents
Neuromuscular Blocking Agents
Neuromuscular Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anticholesteremic Agents
Hypolipidemic Agents
Molecular Mechanisms of Pharmacological Action
Enzyme Inhibitors
Lipid Regulating Agents processed this record on May 25, 2017