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Aerobic Exercise to Improve Executive Language Function In Older Adults

This study has been completed.
Information provided by (Responsible Party):
VA Office of Research and Development Identifier:
First received: September 15, 2009
Last updated: November 13, 2014
Last verified: November 2014
The purpose of this study is to see if exercise can improve brain function in older adults

Condition Intervention
Behavioral: Aerobic group

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Aerobic Exercise to Improve Executive Language Function in Older Adults

Resource links provided by NLM:

Further study details as provided by VA Office of Research and Development:

Primary Outcome Measures:
  • Executive Language Functions [ Time Frame: number of correct words at pre and post separated by 12 weeks ]
    The Verbal Fluency Test is demonstrated to be reliable and valid among adults aged 50 to 89 (Delis, et al., 2001; Delis, Kramer, Kaplan, & Hodnack, 2004). The Verbal Fluency Test has three conditions, Letter Verbal Fluency, Category Verbal Fluency, and Switching Verbal Fluency. Each was randomized at pre- and post-12 week timeline and equated for difficulty. Letter Verbal Fluency assesses the number of words beginning with certain letters that participants can generate within 60 seconds,the Category Verbal Fluency assesses the number of words within particular categories participants can generate within 60 seconds, and the Switching Verbal Fluency assesses the number of words while alternating between different categories participants can generate within 60 seconds. For each condition (letter, category, and switching) a total score representing the total number of correct

Enrollment: 20
Study Start Date: September 2010
Study Completion Date: January 2012
Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Aerobic Group
12 weeks of aerobic exercise 3 times a week
Behavioral: Aerobic group
12 weeks of aerobic exercise 3 times a week
No Intervention: Control Group
No contact control

Detailed Description:
Recently, considerable attention has been devoted to examining the beneficial relationship between cognition and aerobic exercise in older adults. Specifically, the effects are thought to involve higher order cognitive processes, such as working memory, switching between tasks, and inhibiting irrelevant information, all of which are thought to be sub- served, in part, by the frontal lobes (Colcombe et al., 2006). Importantly, these areas also are most susceptible to age-related decline (Raz, 2000) and are essential resources for language production (Kemper & Sumner, 2001; Murray & Lenz, 2001). However, despite promising cognitive improvement, changes in frontally-mediated executive language functions have been widely ignored. This is unfortunate considering impaired word retrieval compromises communicative effectiveness, leading to frustration, depression, and withdrawal. Perhaps more importantly, communication ineffectiveness, particularly in the elderly, leads to difficulties interacting with health care professionals leading to further health care burdens. Since cognition, and specifically word retrieval difficulties, usually remain untreated, it is important to find treatment strategies for minimizing these deficits. Therefore, the short-term goal and the purpose of this proposal is to examine the potential of aerobic exercise to improve executive language function in older adults.

Ages Eligible for Study:   65 Years to 89 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Consent of participants' primary health care physicians to participate in the aerobic exercise.
  • Patients must not have participated in any consistent exercise program or experimental study for at least 3 months prior to enrollment.
  • They must be capable of providing informed consent and complying with the trial procedures.

Exclusion Criteria:

  • Demented as defined by the Modified Mini Mental Status Exam.
  • Unalterable travel schedules.
  • Site accessibility constraints.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00979069

United States, Florida
North Florida/South Georgia Veterans Health System, Gainesville, FL
Gainesville, Florida, United States, 32608
United States, Georgia
Atlanta VA Medical and Rehab Center, Decatur, GA
Decatur, Georgia, United States, 30033
Sponsors and Collaborators
VA Office of Research and Development
Principal Investigator: Joe R Nocera, PhD Atlanta VA Medical and Rehab Center, Decatur, GA
  More Information

Responsible Party: VA Office of Research and Development Identifier: NCT00979069     History of Changes
Other Study ID Numbers: E6860-M
Study First Received: September 15, 2009
Results First Received: September 18, 2014
Last Updated: November 13, 2014 processed this record on May 22, 2017