Light Treatment for Sleep/Wake Disturbances in Alzheimer's Disease
|ClinicalTrials.gov Identifier: NCT00946530|
Recruitment Status : Completed
First Posted : July 27, 2009
Results First Posted : March 29, 2017
Last Update Posted : March 29, 2017
|Condition or disease||Intervention/treatment|
|Sleep Initiation and Maintenance Disorders||Device: Bright light Device: Control|
- Efficacy: Up to 4 weeks of morning bright light exposure will be more efficacious than morning dim light in consolidating nighttime sleep as assessed by actigraphy.
- Predictors of response: We expect the primary predictor of treatment response will be initial MMSE score. Secondary predictors include baseline sleep/wake and circadian parameters and age.
- Effectiveness: Bright light treatment will be more effective than dim light in improving quality of life.
- An understanding of some of the genetic markers of memory and/or sleep problems.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||118 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Triple (Participant, Care Provider, Outcomes Assessor)|
|Official Title:||Light Treatment for Sleep/Wake Disturbances in Alzheimer's Disease|
|Study Start Date :||September 2004|
|Primary Completion Date :||December 2010|
|Study Completion Date :||December 2010|
Experimental: Bright Light
received bright light
Device: Bright light
Participants uses bright light
Placebo Comparator: Control
received regular light
Participants uses dim light
- Total Sleep Time [ Time Frame: 2 weeks ]The amount of actual sleep time in a sleep episode.
- WASO (Wake After Sleep Onset) [ Time Frame: 2 weeks ]WASO (Wake After Sleep Onset): the amount of time test subjects have spent awake after initially falling sleep and before they awaken for good.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00946530
|United States, California|
|VA Palo Alto Health Care System|
|Palo Alto, California, United States, 94304|
|Principal Investigator:||Jerome A Yesavage||Stanford University|