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SWOG-9245 Collecting and Storing Tissue Samples From Patients With Relapsed or Recurrent Non-Hodgkin Lymphoma After Treatment on a Southwest Oncology Group Clinical Trial

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00898872
First Posted: May 12, 2009
Last Update Posted: May 20, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Southwest Oncology Group
  Purpose

RATIONALE: Collecting and storing samples of tissue from patients with non-Hodgkin lymphoma to study in the laboratory may help the study of cancer in the future.

PURPOSE: This laboratory study is collecting and storing tissue samples from patients with relapsed or recurrent non-Hodgkin lymphoma after treatment on a Southwest Oncology Group (SWOG) clinical trial.


Condition Intervention
Lymphoma Other: cryopreservation

Study Type: Observational
Study Design: Time Perspective: Retrospective
Official Title: Central Lymphoma Repository Tissue Procurement Protocol for Relapse or Recurrent Disease

Resource links provided by NLM:


Further study details as provided by Southwest Oncology Group:

Primary Outcome Measures:
  • Acquisition of snap-frozen lymphoma tissues [ Time Frame: July 2011 ]

Enrollment: 32
Study Start Date: March 1993
Study Completion Date: July 2011
Primary Completion Date: July 2011 (Final data collection date for primary outcome measure)
Detailed Description:

OBJECTIVES:

  • Acquire fresh snap-frozen lymphoma tissue from patients with relapsed or recurrent non-Hodgkin lymphoma after treatment on a Southwest Oncology Group (SWOG) clinical trial.
  • Establish a standard set of procedures for routine acquisition, banking, and study of lymphoma tissues within the SWOG.
  • Use repository tissue to establish clinical correlations via presently activated phenotyping studies and future projected molecular studies assessing specimen DNA and RNA status.
  • Examine the biology of therapy failure in relationship to changes in pretreatment and post-treatment immunophenotypic data.

OUTLINE: This is a multicenter study.

Tissues collected at biopsy are snap-frozen and archived for future molecular and genetic studies.

PROJECTED ACCRUAL: Not specified

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients who consented to SWOG 9245 for banking
Criteria

DISEASE CHARACTERISTICS:

  • Diagnosis of relapsed or recurrent non-Hodgkin lymphoma (NHL)
  • Previously registered on 1 of the following SWOG clinical trials for previously untreated NHL:

    • SWOG-8410
    • SWOG-8503
    • SWOG-8508
    • SWOG-8516
    • SWOG-8736
    • SWOG-8809
    • SWOG-8907
    • SWOG-8954
    • SWOG-9125
    • SWOG-9240
    • SWOG-9320
    • SWOG-9349
    • SWOG-9432
    • SWOG-9501
    • SWOG-9703
    • SWOG-S9704
    • SWOG-9800
  • Tissue samples of relapsed or recurrent disease available

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00898872


  Show 82 Study Locations
Sponsors and Collaborators
Southwest Oncology Group
National Cancer Institute (NCI)
Investigators
Study Chair: Thomas Grogan, MD University of Arizona
Study Chair: Thomas P. Miller, MD University of Arizona
Study Chair: Richard I. Fisher, MD James P. Wilmot Cancer Center
  More Information

Responsible Party: Southwest Oncology Group
ClinicalTrials.gov Identifier: NCT00898872     History of Changes
Other Study ID Numbers: CDR0000455162
SWOG-9245 ( Other Identifier: SWOG )
U10CA032102 ( U.S. NIH Grant/Contract )
First Submitted: May 9, 2009
First Posted: May 12, 2009
Last Update Posted: May 20, 2013
Last Verified: May 2013

Keywords provided by Southwest Oncology Group:
recurrent grade 3 follicular lymphoma
recurrent adult diffuse small cleaved cell lymphoma
recurrent adult diffuse mixed cell lymphoma
recurrent adult diffuse large cell lymphoma
recurrent adult immunoblastic large cell lymphoma
recurrent adult lymphoblastic lymphoma
recurrent adult Burkitt lymphoma
recurrent adult grade III lymphomatoid granulomatosis
recurrent grade 1 follicular lymphoma
recurrent grade 2 follicular lymphoma
recurrent mantle cell lymphoma
recurrent marginal zone lymphoma
recurrent small lymphocytic lymphoma
extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue
nodal marginal zone B-cell lymphoma
splenic marginal zone lymphoma
Waldenström macroglobulinemia
adult nasal type extranodal NK/T-cell lymphoma
recurrent childhood grade III lymphomatoid granulomatosis
recurrent childhood large cell lymphoma
recurrent childhood lymphoblastic lymphoma
recurrent childhood small noncleaved cell lymphoma
childhood diffuse large cell lymphoma
childhood immunoblastic large cell lymphoma
childhood Burkitt lymphoma
childhood nasal type extranodal NK/T-cell lymphoma

Additional relevant MeSH terms:
Lymphoma
Neoplasms by Histologic Type
Neoplasms
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases