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Computer Stop Order Alert to Prevent Concurrent Prescribing of Trimethoprim/Sulfamethoxazole and Warfarin (warf-tmp/smx)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00870298
Recruitment Status : Terminated (four adverse events encountered)
First Posted : March 27, 2009
Last Update Posted : December 9, 2015
Information provided by (Responsible Party):
University of Pennsylvania

Brief Summary:
To determine if a computerized stop order will reduce the number of concurrent trimethoprim/sulfamethoxazole and warfarin orders accepted through the inpatient electronic ordering system while a patient is hospitalized.

Condition or disease Intervention/treatment Phase
Prescribers' Drug Orders Drug: Trimethoprim/Sulfamethoxazole and Warfarin Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 1971 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Official Title: Randomized Controlled Study of a Computer Stop Order Versus Routine Practice When Trimethoprim/Sulfamethoxazole is Ordered Concurrently With Warfarin
Study Start Date : August 2006
Actual Primary Completion Date : January 2007
Actual Study Completion Date : January 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Blood Thinners

Arm Intervention/treatment
Experimental: computerized alert
An automatic electronic stop of the tmp/sulfa or warfarin order whenever a resident or nurse practitioner places an order for tmp/sulfa with an already active warfarin order, or when ordering both simultaneously
Drug: Trimethoprim/Sulfamethoxazole and Warfarin
2 Current practice
Current practice of the pharmacist recommending cessation of concurrent warfarin and tmp/sulfa orders
Drug: Trimethoprim/Sulfamethoxazole and Warfarin

Primary Outcome Measures :
  1. Reduce concomitant orders for warfarin and tmp/smx [ Time Frame: 7 months ]

Secondary Outcome Measures :
  1. Determine if computerized stop order will increase risk for inadvertent cessation of warfarin [ Time Frame: 7 months ]
  2. Determine if computerized stop order will increase risk of delay of treatment with tmp/sulfa when determined to be necessary for treatment [ Time Frame: 7 months ]

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

All resident physicians and nurse practitioners involved in inpatient care.

Exclusion Criteria:


Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: University of Pennsylvania Identifier: NCT00870298     History of Changes
Other Study ID Numbers: 803788
First Posted: March 27, 2009    Key Record Dates
Last Update Posted: December 9, 2015
Last Verified: December 2015
Keywords provided by University of Pennsylvania:
drug orders
Additional relevant MeSH terms:
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Anti-Infective Agents, Urinary
Anti-Infective Agents
Renal Agents
Antiprotozoal Agents
Antiparasitic Agents
Folic Acid Antagonists
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-Dyskinesia Agents
Cytochrome P-450 CYP2C8 Inhibitors
Cytochrome P-450 Enzyme Inhibitors