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Investigating Physiological Adaptations to Weight Loss

This study has been completed.
Information provided by (Responsible Party):
Priya Sumithran, University of Melbourne Identifier:
First received: March 26, 2009
Last updated: December 3, 2014
Last verified: December 2014
The purpose of this study is to examine the effect of diet-induced weight loss on the levels of circulating nutrients and hormones which are involved in feelings of hunger and satiety.

Condition Intervention
Dietary Supplement: Optifast VLCD

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: An Investigation of Physiological Adaptations Contributing to Weight Regain After Weight Loss

Resource links provided by NLM:

Further study details as provided by Priya Sumithran, University of Melbourne:

Primary Outcome Measures:
  • Difference in fasting and/or post-prandial hormone levels following weight loss and after weight maintenance compared with baseline [ Time Frame: 2, 6 and 12 months ]

Secondary Outcome Measures:
  • Difference in fasting and/or post-prandial hormone levels in ketotic compared with non-ketotic state [ Time Frame: week 8 vs week 10 ]
  • Correlation of fasting and post-prandial hormone levels with ratings of hunger and satiety [ Time Frame: 0, 2, 6 and 12 months ]
  • Association of psychosocial factors with successful weight maintenance [ Time Frame: 12 months ]

Enrollment: 50
Study Start Date: February 2008
Study Completion Date: December 2009
Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Intervention Details:
    Dietary Supplement: Optifast VLCD
    Meal replacement, three times daily for 8 weeks

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • males and post-menopausal females
  • aged over 18 years
  • BMI 27-40kg/m2
  • weight-stable

Exclusion Criteria:

  • major comorbid medial condition (including diabetes)
  • taking medications known to affect weight
  • smoking
  Contacts and Locations
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Please refer to this study by its identifier: NCT00870259

Australia, Victoria
Heidelberg Repatriation Hospital
Melbourne, Victoria, Australia, 3081
Sponsors and Collaborators
University of Melbourne
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Priya Sumithran, Clinical research fellow, University of Melbourne Identifier: NCT00870259     History of Changes
Other Study ID Numbers: HP 508920
Study First Received: March 26, 2009
Last Updated: December 3, 2014

Keywords provided by Priya Sumithran, University of Melbourne:
Weight loss
Weight maintenance

Additional relevant MeSH terms:
Weight Loss
Body Weight Changes
Body Weight
Signs and Symptoms processed this record on May 25, 2017