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Predictors of Neuro-cognitive Decline and Survival in HIV-infected Subjects

This study has been completed.
Thai Red Cross AIDS Research Centre
Information provided by:
South East Asia Research Collaboration with Hawaii Identifier:
First received: March 17, 2009
Last updated: May 2, 2011
Last verified: March 2009

Patients will be followed every 6 months for a total of 5 visits (Month 0, 6, 12, 18 and 24). The first visit is the screening and entry visit which can occur at any time after the subject finishes SEARCH 001 study but preferably it should occur approximately 6 months after SEARCH 001 study completion.

At each visit, patients will undergo the following

  1. Assessment of function including activity of daily living questionnaire
  2. History of medical illnesses, medication history
  3. Neurological examination: All patients will have a neurological evaluation and neuropsychological evaluation to characterize neurocognitive and neurological status. (It is possible that patients within the non-dementia group will meet criteria for dementia after close testing is completed).
  4. Neuropsychological assessment:
  5. Thai Depression Inventory.
  6. HIV viral load and storage of blood for proviral DNA level

Final outcome assessment based on all available data. If possible, it is intended that these diagnoses will be determined through monthly VTC conference calls with UH investigators. This consensus conference will include the Thai investigators, the UH neurologist, the UH neuropsychologist and the UH principal investigators.


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by South East Asia Research Collaboration with Hawaii:

Enrollment: 60
Study Start Date: August 2007
Study Completion Date: April 2011
Primary Completion Date: April 2011 (Final data collection date for primary outcome measure)
HIV-infected, no dementia
Patients with HIV-infection but no dementia
HIV-infected, dementia
Patients with HIV-infection and dementia


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
primary care clinic

Inclusion Criteria:

  • All patients who have completed the SEARCH 001 study are eligible to enroll in this SEARCH 001.1 study provided that they understand and voluntarily sign the informed consent form.

Exclusion Criteria:

  Contacts and Locations
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Please refer to this study by its identifier: NCT00864292

South East Asia Research Collaboration with Hawaii
Bangkok, Thailand, 10330
Sponsors and Collaborators
South East Asia Research Collaboration with Hawaii
Thai Red Cross AIDS Research Centre
Principal Investigator: Jintanat Ananworanich, PhD South East Asia Research Collaboration with Hawaii
  More Information

Responsible Party: Victor Valcour, John A. Burns School of Medicine, Honolulu, Hawaii Identifier: NCT00864292     History of Changes
Other Study ID Numbers: SEARCH 001.1
Study First Received: March 17, 2009
Last Updated: May 2, 2011

Additional relevant MeSH terms:
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurocognitive Disorders
Mental Disorders processed this record on April 26, 2017