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Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery

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ClinicalTrials.gov Identifier: NCT00833313
Recruitment Status : Recruiting
First Posted : February 2, 2009
Last Update Posted : March 12, 2018
Sponsor:
Information provided by (Responsible Party):
Jochen Daniel Muehlschlegel, MD, Brigham and Women's Hospital

Brief Summary:
Atrial fibrillation is a type of irregular heartbeat that is common after having heart surgery. There may be many different reasons why some people get atrial fibrillation after their heart surgery. These reasons may include that a person is older or that he/she is taking certain types of medications before surgery. Genes may also be a reason. Genes contain the material passed from parent to child that determines the make-up of the body and mind. For example, some genes control the color of your hair or eyes. Some people may have genes that make it more likely for them to get atrial fibrillation after their heart surgery. This research project is being done to find out if the cells of people who develop atrial fibrillation after heart surgery are different from the cells in people who do not develop atrial fibrillation after surgery.

Condition or disease Intervention/treatment
Atrial Fibrillation Other: Atrial biopsy

Detailed Description:

Atrial fibrillation is a type of irregular heartbeat that is common after having heart surgery. There may be many different reasons why some people get atrial fibrillation after their heart surgery. These reasons may include that a person is older or that he/she is taking certain types of medications before surgery. Genes may also be a reason. Genes contain the material passed from parent to child that determines the make-up of the body and mind. For example, some genes control the color of your hair or eyes. Some people may have genes that make it more likely for them to get atrial fibrillation after their heart surgery. This research project is being done to find out if the cells of people who develop atrial fibrillation after heart surgery are different from the cells in people who do not develop atrial fibrillation after surgery.

This study seeks to identify regulatory events in atrial myocyte transcription and translation that are altered by germline variation


Study Type : Observational
Estimated Enrollment : 240 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery
Study Start Date : August 2008
Estimated Primary Completion Date : August 2018
Estimated Study Completion Date : August 2018

Resource links provided by the National Library of Medicine

U.S. FDA Resources


Intervention Details:
    Other: Atrial biopsy
    Biopsy of right atrial free wall


Primary Outcome Measures :
  1. Gene expression [ Time Frame: Immediate ]

Biospecimen Retention:   Samples With DNA
Atrial tissue sample


Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Adult patients undergoing cardiac surgery
Criteria

Inclusion Criteria:

  • Age 20-80 years
  • Undergoing cardiac surgery

Exclusion Criteria:

  • Prior atrial fibrillation or flutter
  • Taking Amiodarone
  • Taking Sotalol

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00833313


Contacts
Contact: Simon C Body, MD 617-732-7330 sbody@partners.org

Locations
United States, Massachusetts
Brigham and Women's Hospital Recruiting
Boston, Massachusetts, United States, 02115
Contact: Simon C Body, MBChB    617-732-7330    sbody@bwh.harvard.edu   
Sub-Investigator: Jochen D Muehlschlegel, MD         
Sponsors and Collaborators
Brigham and Women's Hospital
Investigators
Principal Investigator: Simon C Body, MD Brigham and Women's Hospital

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Jochen Daniel Muehlschlegel, MD, Associate Professor, Brigham and Women's Hospital
ClinicalTrials.gov Identifier: NCT00833313     History of Changes
Other Study ID Numbers: 2008-P000896
First Posted: February 2, 2009    Key Record Dates
Last Update Posted: March 12, 2018
Last Verified: March 2018

Keywords provided by Jochen Daniel Muehlschlegel, MD, Brigham and Women's Hospital:
Atrial fibrillation
Gene expression
Genetic

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes