Effect of Helicobacter Pylori Treatment on Idiopathic Central Serous Chorioretinopathy (ICSCR) (ICSCR)

This study has been completed.
Information provided by:
Tabriz University
ClinicalTrials.gov Identifier:
First received: January 1, 2009
Last updated: January 5, 2009
Last verified: January 2009
Etiology of ICSCR is not known however recent studies regard the role of immunologic and infectious processes in the pathogenesis of ICSCR.one of these hypothesis is the role of helicobacter pylori in the pathogenesis of ICSCR so perhaps treatment of h pylori have positive effect on the remission of ICSCR.

Condition Intervention Phase
Central Serous Chorioretinopathy
Drug: omeprazole, Amoxicillin, metronidazole
Phase 1
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Treatment
Official Title: Effect of Helicobacter Pylori Treatment on Remission of Idiopathic Central Serous Chorioretinopathy (ICSCR)

Resource links provided by NLM:

Further study details as provided by Tabriz University:

Primary Outcome Measures:
  • Subretinal fluid level [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • time of sub macular fluid absorption [ Designated as safety issue: Yes ]

Enrollment: 50
Study Start Date: March 2008
Study Completion Date: January 2009
Primary Completion Date: October 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: 1
Oral Amoxicillin Capsule Metronidazole Tablet Omeprazole Capsule
Drug: omeprazole, Amoxicillin, metronidazole
we will evaluate the effect of medication(anti h.pylori) on the remission of ICSCR
Other Name: treatment of Central serous chorioretinopathy
No Intervention: 2
No medical treatment

Detailed Description:
we will choose 50 cases of patients with ICSCR who are infected with h.pylori.25 cases will receive anti h.pylori regiment and 25 cases as controls will receive no medication.then we will compare the time of submacular fluid resorption and macular thickness and visual acuity among these two groups.

Ages Eligible for Study:   28 Years to 40 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • the persons who are infected with helicobacter pylori and have ICSCR

Exclusion Criteria:

  • history of previous eye surgery ,to have indication of laser therapy,corticosteroid therapy,pregnancy,
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00817245

Iran, Islamic Republic of
Alireza JavadzadehTabriz
Tabriz, Iran, Islamic Republic of
Sponsors and Collaborators
Tabriz University
Study Chair: Alireza Javadzadeh Alireza Javadzadeh
  More Information

Responsible Party: Alireza Javadzadeh, Tabriz University of Medical Sciences
ClinicalTrials.gov Identifier: NCT00817245     History of Changes
Other Study ID Numbers: 86-47 
Study First Received: January 1, 2009
Last Updated: January 5, 2009
Health Authority: Iran: Ethics Committee

Keywords provided by Tabriz University:
Helicobacter pylori

Additional relevant MeSH terms:
Central Serous Chorioretinopathy
Eye Diseases
Retinal Diseases
Anti-Bacterial Agents
Anti-Infective Agents
Anti-Ulcer Agents
Antiparasitic Agents
Antiprotozoal Agents
Enzyme Inhibitors
Gastrointestinal Agents
Molecular Mechanisms of Pharmacological Action
Proton Pump Inhibitors

ClinicalTrials.gov processed this record on May 25, 2016