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Effect of Helicobacter Pylori Treatment on Idiopathic Central Serous Chorioretinopathy (ICSCR) (ICSCR)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00817245
First Posted: January 6, 2009
Last Update Posted: October 12, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Tabriz University
  Purpose
Etiology of ICSCR is not known however recent studies regard the role of immunologic and infectious processes in the pathogenesis of ICSCR.one of these hypothesis is the role of helicobacter pylori in the pathogenesis of ICSCR so perhaps treatment of h pylori have positive effect on the remission of ICSCR.

Condition Intervention Phase
Central Serous Chorioretinopathy Drug: omeprazole, Amoxicillin, metronidazole Phase 1 Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Investigator)
Primary Purpose: Treatment
Official Title: Effect of Helicobacter Pylori Treatment on Remission of Idiopathic Central Serous Chorioretinopathy (ICSCR)

Resource links provided by NLM:


Further study details as provided by Tabriz University:

Primary Outcome Measures:
  • Subretinal fluid level

Secondary Outcome Measures:
  • time of sub macular fluid absorption

Enrollment: 50
Study Start Date: March 2008
Study Completion Date: January 2009
Primary Completion Date: October 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: 1
Oral Amoxicillin Capsule Metronidazole Tablet Omeprazole Capsule
Drug: omeprazole, Amoxicillin, metronidazole
we will evaluate the effect of medication(anti h.pylori) on the remission of ICSCR
Other Name: treatment of Central serous chorioretinopathy
No Intervention: 2
No medical treatment

Detailed Description:
we will choose 50 cases of patients with ICSCR who are infected with h.pylori.25 cases will receive anti h.pylori regiment and 25 cases as controls will receive no medication.then we will compare the time of submacular fluid resorption and macular thickness and visual acuity among these two groups.
  Eligibility

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Ages Eligible for Study:   28 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • the persons who are infected with helicobacter pylori and have ICSCR

Exclusion Criteria:

  • history of previous eye surgery ,to have indication of laser therapy,corticosteroid therapy,pregnancy,
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00817245


Locations
Iran, Islamic Republic of
Alireza JavadzadehTabriz
Tabriz, Iran, Islamic Republic of
Sponsors and Collaborators
Tabriz University
Investigators
Study Chair: Alireza Javadzadeh Alireza Javadzadeh
  More Information

Responsible Party: Alireza Javadzadeh, Tabriz University of Medical Sciences
ClinicalTrials.gov Identifier: NCT00817245     History of Changes
Other Study ID Numbers: 86-47
First Submitted: January 1, 2009
First Posted: January 6, 2009
Last Update Posted: October 12, 2017
Last Verified: January 2009

Keywords provided by Tabriz University:
CSR
Helicobacter pylori

Additional relevant MeSH terms:
Central Serous Chorioretinopathy
Retinal Diseases
Eye Diseases
Amoxicillin
Metronidazole
Omeprazole
Anti-Bacterial Agents
Anti-Infective Agents
Antiprotozoal Agents
Antiparasitic Agents
Anti-Ulcer Agents
Gastrointestinal Agents
Proton Pump Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action