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Bleb Vascularity Change After Subconjunctival Injection Bevacizumab

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified December 2008 by Capital Medical University.
Recruitment status was:  Active, not recruiting
Information provided by:
Capital Medical University Identifier:
First received: December 29, 2008
Last updated: NA
Last verified: December 2008
History: No changes posted
The occurrence of conjunctival scarring finally leads to the obstruction of the fistula tract created by the filtering surgery. Vascular endothelial growth factor is thought to be a key role in the formation of conjunctival scar, which play a pivotal role in the wound-healing process. So it seems that the recombinant human anti-VEGF antibody could inhibit angiogenesis, and reduce the conjunctival vascular formation in the wound-healing process after glaucoma filtering surgery.

Condition Intervention Phase
Bleb Vascularity
Conjunctival Scarring
Drug: bevacizumab
Phase 4

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Bleb Vascularity Change After Subconjunctival Injection of Bevacizumab

Resource links provided by NLM:

Further study details as provided by Capital Medical University:

Primary Outcome Measures:
  • bleb vascular change [ Time Frame: one day, one week, one month ]

Estimated Enrollment: 30
Study Start Date: December 2008
Estimated Study Completion Date: May 2009
Estimated Primary Completion Date: March 2009 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: bevacizumab
    0.05ml, 1.25mg

Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Glaucoma patients after trabeculectomy whose bleb is hyperaemia

Exclusion Criteria:

  • Affected eye has normal IOP
  • Not allergic with Avastin
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Please refer to this study by its identifier: NCT00815594

China, Beijing
Tongren hospital
Beijing, Beijing, China, 100730
Sponsors and Collaborators
Capital Medical University
Principal Investigator: Liu Xuan, M.D. An ophthalmologist in Tongren hospital
  More Information

Responsible Party: Wang NingLi, Beiing Tongren hospital Identifier: NCT00815594     History of Changes
Other Study ID Numbers: 2008TR-LX-001
Study First Received: December 29, 2008
Last Updated: December 29, 2008

Keywords provided by Capital Medical University:
vascular change
Bleb vascularity associated with increased scarring activity
Conjunctival scarring finally leads to the obstruction of the fistula tract created by the filtering surgery
the recombinant human anti-VEGF antibody could inhibit angiogenesis of conjunctiva.

Additional relevant MeSH terms:
Pathologic Processes
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Physiological Effects of Drugs
Growth Inhibitors
Antineoplastic Agents processed this record on May 25, 2017