Bleb Vascularity Change After Subconjunctival Injection Bevacizumab

The recruitment status of this study is unknown because the information has not been verified recently.
Verified December 2008 by Capital Medical University.
Recruitment status was  Active, not recruiting
Information provided by:
Capital Medical University Identifier:
First received: December 29, 2008
Last updated: NA
Last verified: December 2008
History: No changes posted
The occurrence of conjunctival scarring finally leads to the obstruction of the fistula tract created by the filtering surgery. Vascular endothelial growth factor is thought to be a key role in the formation of conjunctival scar, which play a pivotal role in the wound-healing process. So it seems that the recombinant human anti-VEGF antibody could inhibit angiogenesis, and reduce the conjunctival vascular formation in the wound-healing process after glaucoma filtering surgery.

Condition Intervention Phase
Bleb Vascularity
Conjunctival Scarring
Drug: bevacizumab
Phase 4

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Bleb Vascularity Change After Subconjunctival Injection of Bevacizumab

Resource links provided by NLM:

Further study details as provided by Capital Medical University:

Primary Outcome Measures:
  • bleb vascular change [ Time Frame: one day, one week, one month ] [ Designated as safety issue: No ]

Estimated Enrollment: 30
Study Start Date: December 2008
Estimated Study Completion Date: May 2009
Estimated Primary Completion Date: March 2009 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: bevacizumab
    0.05ml, 1.25mg

Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Glaucoma patients after trabeculectomy whose bleb is hyperaemia

Exclusion Criteria:

  • Affected eye has normal IOP
  • Not allergic with Avastin
  Contacts and Locations
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Please refer to this study by its identifier: NCT00815594

China, Beijing
Tongren hospital
Beijing, Beijing, China, 100730
Sponsors and Collaborators
Capital Medical University
Principal Investigator: Liu Xuan, M.D. An ophthalmologist in Tongren hospital
  More Information

Responsible Party: Wang NingLi, Beiing Tongren hospital Identifier: NCT00815594     History of Changes
Other Study ID Numbers: 2008TR-LX-001 
Study First Received: December 29, 2008
Last Updated: December 29, 2008
Health Authority: China: Ethics Committee

Keywords provided by Capital Medical University:
vascular change
Bleb vascularity associated with increased scarring activity
Conjunctival scarring finally leads to the obstruction of the fistula tract created by the filtering surgery
the recombinant human anti-VEGF antibody could inhibit angiogenesis of conjunctiva.

Additional relevant MeSH terms:
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Antineoplastic Agents
Growth Inhibitors
Growth Substances
Physiological Effects of Drugs processed this record on May 26, 2016