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The Effects of Linezolid and Vancomycin on Inflammation and Cellular Signaling Vents

This study has been completed.
Information provided by (Responsible Party):
University of Utah Identifier:
First received: December 17, 2008
Last updated: November 23, 2011
Last verified: November 2011
We will determine if linezolid inhibits cellular activation and production of pro-inflammatory cytokines, providing mechanistic rationale for its clinical efficacy and the justification for further investigations in S. Aureus sepsis.

Condition Intervention
Drug: Linezolid or Vancomycin

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: The Effects of Linezolid and Vancomycin on Inflammation and Cellular Signaling Vents

Resource links provided by NLM:

Further study details as provided by University of Utah:

Primary Outcome Measures:
  • IL-6 [ Time Frame: 12 Months ]
    Measurement of IL-6 release in response to MRSA.

Secondary Outcome Measures:
  • MCP-1 [ Time Frame: 12 Months ]
    Measurement of MCP-1 release in response to MRSA.

Biospecimen Retention:   Samples Without DNA
Whole blood

Enrollment: 60
Study Start Date: January 2009
Study Completion Date: June 2010
Primary Completion Date: June 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Heathy Subjects Drug: Linezolid or Vancomycin
Whole blood samples from healthy subjects will be incubated with MRSA bacterium or bacterial toxins in the presence and absence of either linezolid or vancomycin. Final concentrations will mimic physiologic conditions. Platelets and leukocytes will be isolated and assayed for the presence of absence of activation and pre-mRNA splicing.
Other Name: Zyvox


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy subjects who consent to donate blood.

Inclusion Criteria:

  • Healthy, taking no medications, and not recently hospitalized

Exclusion Criteria:

  • Infection (active)
  Contacts and Locations
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Please refer to this study by its identifier: NCT00811980

Sponsors and Collaborators
University of Utah
Principal Investigator: Guy Zimmerman, MD University of Utah
  More Information

Responsible Party: University of Utah Identifier: NCT00811980     History of Changes
Other Study ID Numbers: 00392
Pfizer GA5951WK
Study First Received: December 17, 2008
Last Updated: November 23, 2011

Additional relevant MeSH terms:
Pathologic Processes
Anti-Bacterial Agents
Anti-Infective Agents
Protein Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action processed this record on May 24, 2017