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Derivation of Induced Pluripotent Stem Cells From an Existing Collection of Human Somatic Cells

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ClinicalTrials.gov Identifier: NCT00801333
Recruitment Status : Recruiting
First Posted : December 3, 2008
Last Update Posted : August 16, 2022
Information provided by (Responsible Party):
Benjamin Reubinoff, Hadassah Medical Organization

Brief Summary:

Induced pluripotent stem cells potentially may be useful in the future as an unlimited source of cells for transplantation.

The major goal of the project is to develop human iPS cells from various types of cell cultures or lines from existing collections. The IPS cells will be developed for modeling diseases, for developing the technology that may eventually allow the use of IPS cells for transplantation therapy, and for basic research.

Condition or disease
Amyotrophic Lateral Sclerosis

Detailed Description:

The potential to reprogram somatic cells into an embryonic state raises multiple basic research questions related both to the process of reprogramming and the properties of iPS cells. We will use various approaches to study the molecular mechanisms and processes that occur during reprogramming. We will use various experimental systems to characterize and study the properties of the iPS cells, their biology, developmental potential, capability to give rise to functional differentiated progeny etc.

We will induce the differentiation of the iPS cells towards specific cell lineages and the progeny can be used to study the pathogenesis of diseases. They will be used for developing new therapeutic approaches and for high throughput screening of factors for potential toxic or therapeutic effects.

All samples will be non-identified.

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Study Type : Observational
Estimated Enrollment : 25 participants
Observational Model: Other
Time Perspective: Prospective
Official Title: Derivation of Induced Pluripotent Stem Cells From an Existing Collection of Human Somatic Cells
Actual Study Start Date : November 2008
Estimated Primary Completion Date : December 2025
Estimated Study Completion Date : December 2025

Biospecimen Retention:   Samples With DNA
Existing banks of collected cells maintained.

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
We will use human somatic cells from existing collections.

Inclusion Criteria:

  • Volunteers
  • Male and Female

Exclusion Criteria:

  • Below the official age of consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00801333

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Contact: Benjamin E. Reubinoff, M.D. PhD. 011-972-2-677-4569 benjaminr@ekmd.huji.ac.il
Contact: Shelly E Tannenbaum, MSQA 011-972-2-677-7945 stannenbaum@hadassah.org.il

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Hadassah Medical Organization - Ein Kerem Campus Recruiting
Jerusalem, Israel, 91120
Contact: Hadas Lemberg, PhD    011-972-2-677-6095    Lhadas@hadassah.org.il   
Hadassah Ein Kerem Recruiting
Jerusalem, Israel, 9112100
Contact: Benjamin E Reubinoff, Professor    972-2-6776424/5    benr@hadassah.org.il   
Contact: Shelly E Tannenbaum, MSQA    972-2-6777945    stannenbaum@hadassah.org.il   
Sponsors and Collaborators
Hadassah Medical Organization
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Principal Investigator: Benjamin E Reubinoff, MD PhD Chairman of Department of Obstetrics & Gynecology/IVF, Hadassah Ein Kerem
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Responsible Party: Benjamin Reubinoff, Professor, Hadassah Medical Organization
ClinicalTrials.gov Identifier: NCT00801333    
Other Study ID Numbers: 0511-08-HMO
First Posted: December 3, 2008    Key Record Dates
Last Update Posted: August 16, 2022
Last Verified: August 2022
Keywords provided by Benjamin Reubinoff, Hadassah Medical Organization:
Additional relevant MeSH terms:
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Motor Neuron Disease
Amyotrophic Lateral Sclerosis
Neurodegenerative Diseases
Nervous System Diseases
Neuromuscular Diseases
Spinal Cord Diseases
Central Nervous System Diseases
TDP-43 Proteinopathies
Proteostasis Deficiencies
Metabolic Diseases