Myocilin Variations and Familial Glaucoma in Taxiarchis

This study is currently recruiting participants. (see Contacts and Locations)
Verified May 2014 by Aristotle University Of Thessaloniki
Information provided by (Responsible Party):
AGP Konstas, Aristotle University Of Thessaloniki Identifier:
First received: November 7, 2008
Last updated: May 9, 2014
Last verified: May 2014
Taxiarchis, a small village in Northern Greece with 1060 inhabitants, was considered to have a surprisingly high incidence of glaucoma. This isolated population located on Mount Holomondas appeared to be enriched for familial glaucoma. Based upon the high reported incidence of glaucoma in Taxiarchis and previous findings of the Thr377Met myocilin mutation in the Greek population,the investigators undertook a community-based study to determine if this variant was present in this village.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Myocilin Variations and Familial Glaucoma in Taxiarchis, A Small Greek Village.

Resource links provided by NLM:

Further study details as provided by Aristotle University Of Thessaloniki:

Primary Outcome Measures:
  • Examining all of the villagers to determine the actual incidence of glaucoma in Taxiarchis and identify the Thr377Met myocilin mutation in glaucoma patients. [ Time Frame: 4 years ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA
Myocilin screening was performed from blood or saliva specimens taken from the village. The promoter region and exons 1-3 of myocilin were sequenced at the Portland Veterans Administration Medical center. Microsatellite marker analysis in the GLC1A region, including D1S452, D1S1619, D1S2790 and D1S242 was performed at deCODE (Reykjavik, Iceland).

Estimated Enrollment: 800
Study Start Date: August 2007
Estimated Study Completion Date: December 2016
Estimated Primary Completion Date: June 2016 (Final data collection date for primary outcome measure)
Villagers in Taxiarchis


Ages Eligible for Study:   1 Year to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Villagers from Taxiarchis

Inclusion Criteria:

  • Individuals born in Taxiarchis

Exclusion Criteria:

  • Individuals that have not been born in Taxiarchis
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00788762

Contact: Anastasios G Konstas, MD, PhD 2310-994774
Contact: Georgios Moumtzis, MD 2310-994742

Taxiarchis village Recruiting
Polygyros, Halkidiki, Greece
Sub-Investigator: Antonios Dimopoulos, MD         
Sponsors and Collaborators
Aristotle University Of Thessaloniki
Principal Investigator: Anastasios G Konstas, MD, PhD Glaucoma Unit, 1st University Dept
  More Information

No publications provided

Responsible Party: AGP Konstas, Professor in Ophthalmology, Aristotle University Of Thessaloniki Identifier: NCT00788762     History of Changes
Other Study ID Numbers: A6798
Study First Received: November 7, 2008
Last Updated: May 9, 2014
Health Authority: Greece: National Organization of Medicines

Keywords provided by Aristotle University Of Thessaloniki:

Additional relevant MeSH terms:
Eye Diseases
Ocular Hypertension processed this record on November 27, 2015