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Analysis of Immunological Reactions to Foods in Birch Pollen-Allergic Patients

The recruitment status of this study is unknown because the information has not been verified recently.
Verified October 2008 by Medical University of Vienna.
Recruitment status was  Not yet recruiting
Sponsor:
Information provided by:
Medical University of Vienna
ClinicalTrials.gov Identifier:
NCT00787631
First received: October 23, 2008
Last updated: November 6, 2008
Last verified: October 2008
History of Changes
  Purpose

A high number of birch pollen-allergic individuals develop hypersensitivity reactions to certain foods, e.g. apples. This food allergy is due to immunological cross-reactivity. Birch pollen-related foods contain proteins, e.g. Mal d 1 in apple, that are structurally related with the major birch pollen allergen, Bet v 1. Hence IgE antibodies and T lymphocytes specific for Bet v 1 recognize these food proteins which results in activation of the immune system and, consequently, in clinical symptoms.

In the present study the investigators intend to investigate if and how the consumption of birch pollen-related food allergens affects birch pollen allergy. In other words, the investigators are interested to analyse whether Bet v 1-related food allergens activate Bet v 1-specific memory cells and thus, contribute to the maintenance of the pollen allergy outside the pollen season. Data obtained in this study will help to clarify the immunological and clinical role of cross-reactivity between pollen and food allergies and will reveal whether avoidance of such foods should be recommended for the patients. Finally, novel approaches for diagnosis and therapy of pollen-related food allergens can be developed.


Condition
Allergic Rhinitis
Food Allergy

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Analysis of Immunological Reactions to Pollen-Related Foods in Birch Pollen-Allergic Patients

Resource links provided by NLM:

MedlinePlus related topics: Allergy
U.S. FDA Resources

Further study details as provided by Medical University of Vienna:
Estimated Enrollment: 30
Study Start Date: December 2008
Estimated Study Completion Date: December 2010
Estimated Primary Completion Date: January 2010 (Final data collection date for primary outcome measure)
  Eligibility
Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

otherwise healthy birch pollen allergic (rhinoconjunctivitis)persons suffering also from oral allergy syndrome to apple.

Criteria

Inclusion Criteria:

  • Otherwise healthy birch pollen allergic (rhinoconjunctivitis)persons
  • Positive SPT and RAST to birch pollen
  • Sensitized to Bet v 1

Exclusion Criteria:

  • Persons suffering from malignancies, autoimmune and cardiopulmonary diseases
  • Anemia
  • Hyper-IgE syndrome
  • Treatment with ß-blockers, permanent treatment with antihistaminics, leucotriene antagonists, corticosteroids
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00787631

Contacts
Contact: Tamar Kinaciyan, Ass.Prof.MD +43140400 ext 7700 tamar.kinaciyan@meduniwien.ac.at
Contact: Barbara Bohle, AssocProf Dr +43140400 ext 5114 barbara.bohle@meduniwien.ac.at

Sponsors and Collaborators
Medical University of Vienna
Investigators
Principal Investigator: Tamar Kinaciyan, Ass Prof MD Dept. of Dermatology, Medical University of Vienna
  More Information

No publications provided

Responsible Party: Tamar Kinaciyan, MD, Ass. Prof., DIAID, Dep. of Dermatology, MUV
ClinicalTrials.gov Identifier: NCT00787631     History of Changes
Other Study ID Numbers: TK01/2008
Study First Received: October 23, 2008
Last Updated: November 6, 2008
Health Authority: Austria: Federal Office for Safety in Health Care

Keywords provided by Medical University of Vienna:
birch pollen pollen allergy
oral allergy syndrome to apple
cross reactivity
bet v 1
mal d 1

ClinicalTrials.gov processed this record on March 03, 2015