ClinicalTrials.gov
ClinicalTrials.gov Menu

Analysis of Immunological Reactions to Foods in Birch Pollen-Allergic Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00787631
Recruitment Status : Unknown
Verified October 2008 by Medical University of Vienna.
Recruitment status was:  Not yet recruiting
First Posted : November 7, 2008
Last Update Posted : November 7, 2008
Sponsor:
Information provided by:
Medical University of Vienna

Study Description
Go to 
Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information
Brief Summary:

A high number of birch pollen-allergic individuals develop hypersensitivity reactions to certain foods, e.g. apples. This food allergy is due to immunological cross-reactivity. Birch pollen-related foods contain proteins, e.g. Mal d 1 in apple, that are structurally related with the major birch pollen allergen, Bet v 1. Hence IgE antibodies and T lymphocytes specific for Bet v 1 recognize these food proteins which results in activation of the immune system and, consequently, in clinical symptoms.

In the present study the investigators intend to investigate if and how the consumption of birch pollen-related food allergens affects birch pollen allergy. In other words, the investigators are interested to analyse whether Bet v 1-related food allergens activate Bet v 1-specific memory cells and thus, contribute to the maintenance of the pollen allergy outside the pollen season. Data obtained in this study will help to clarify the immunological and clinical role of cross-reactivity between pollen and food allergies and will reveal whether avoidance of such foods should be recommended for the patients. Finally, novel approaches for diagnosis and therapy of pollen-related food allergens can be developed.


Condition or disease
Allergic Rhinitis Food Allergy

Study Design
Go to 
Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Study Type : Observational
Estimated Enrollment : 30 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Analysis of Immunological Reactions to Pollen-Related Foods in Birch Pollen-Allergic Patients
Study Start Date : December 2008
Estimated Primary Completion Date : January 2010
Estimated Study Completion Date : December 2010
Groups and Cohorts
Go to 
Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information


Outcome Measures
Go to 
Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Eligibility Criteria
Go to 
Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
otherwise healthy birch pollen allergic (rhinoconjunctivitis)persons suffering also from oral allergy syndrome to apple.
Criteria

Inclusion Criteria:

  • Otherwise healthy birch pollen allergic (rhinoconjunctivitis)persons
  • Positive SPT and RAST to birch pollen
  • Sensitized to Bet v 1

Exclusion Criteria:

  • Persons suffering from malignancies, autoimmune and cardiopulmonary diseases
  • Anemia
  • Hyper-IgE syndrome
  • Treatment with ß-blockers, permanent treatment with antihistaminics, leucotriene antagonists, corticosteroids
Contacts and Locations
Go to 
Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00787631


Contacts
Contact: Tamar Kinaciyan, Ass.Prof.MD +43140400 ext 7700 tamar.kinaciyan@meduniwien.ac.at
Contact: Barbara Bohle, AssocProf Dr +43140400 ext 5114 barbara.bohle@meduniwien.ac.at

Sponsors and Collaborators
Medical University of Vienna
Investigators
Principal Investigator: Tamar Kinaciyan, Ass Prof MD Dept. of Dermatology, Medical University of Vienna
More Information
Go to 
Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Responsible Party: Tamar Kinaciyan, MD, Ass. Prof., DIAID, Dep. of Dermatology, MUV
ClinicalTrials.gov Identifier: NCT00787631     History of Changes
Other Study ID Numbers: TK01/2008
First Posted: November 7, 2008    Key Record Dates
Last Update Posted: November 7, 2008
Last Verified: October 2008

Keywords provided by Medical University of Vienna:
birch pollen pollen allergy
oral allergy syndrome to apple
cross reactivity
bet v 1
mal d 1

Additional relevant MeSH terms:
Rhinitis
Hypersensitivity
Rhinitis, Allergic
Food Hypersensitivity
Nose Diseases
Respiratory Tract Diseases
 Respiratory Tract Infections
Otorhinolaryngologic Diseases
Immune System Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate