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A Study on Intima Media Thickness (IMT) in Middle-aged Subjects (IMT)

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ClinicalTrials.gov Identifier: NCT00784264
Recruitment Status : Completed
First Posted : November 3, 2008
Last Update Posted : January 12, 2010
Information provided by:

Brief Summary:
This is an observational study to measure the thickness of artery walls in the neck (intima media thickness IMT) by ultrasound examination in middle-aged subjects with central obesity. The purpose of this study is to obtain local data how common asymptomatic atherosclerosis is, and to investigate the association between Cardiovascular Disease risk factors and intima media thickness (IMT) in the Hong Kong population. Results from this study may enhance the public awareness of asymptomatic atherosclerosis and understand its role in the development of Cardiovascular Disease in Hong Kong.

Condition or disease

Study Type : Observational
Estimated Enrollment : 200 participants
Time Perspective: Prospective
Official Title: A Study on Intima Media Thickness (IMT) in Middle-aged Subjects
Study Start Date : October 2008
Study Completion Date : June 2009

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Atherosclerosis
U.S. FDA Resources

Primary Outcome Measures :
  1. To investigate the prevalence of asymptomatic atherosclerosis by measurement of intima media thickness (IMT) in middle-aged subjects with central obesity in Hong Kong, [ Time Frame: during the one single study visit ]

Secondary Outcome Measures :
  1. To examine the association between IMT value and cardiovascular disease (CVD) risk factors, and blood lipid and glucose profiles in middle-aged centrally obese subjects in Hong Kong. [ Time Frame: During the one single study visit ]
  2. IMT results to be compared with what being reported in the recent literature on normal Chinese population. [ Time Frame: During the one single study visit ]

Information from the National Library of Medicine

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Ages Eligible for Study:   45 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
aged 55 or above with central obesity, male more than 90 cm; female more than 80 cm

Inclusion Criteria:

  • Male or female aged 55 years or above.
  • Waist circumference: male more than 90 cm; female more than 80 cm.

Exclusion Criteria:

  • Any known chronic diseases requiring long-term medication such as hypertension, diabetes and hyperlipidemia.
  • Presence of known cardiovascular diseases including cerebro-vascular disease, coronary heart disease and peripheral artery disease.
  • Presence of any active major diseases that may interfere the physical conditions and body weight of subjects during the study period, which include malignancy, infection, renal or liver function impairment, recent major surgery (within 3 months).

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00784264

Hong Kong
Research Site
Hong Kong, Hong Kong
Sponsors and Collaborators
Study Director: Karen Yuen AstraZeneca Hong Kong Ltd
Principal Investigator: Chun chung Chow, MD Prince of Wales Hospital, Shatin, Hong Kong

Responsible Party: Karen Yuen, AstraZeneca Pharmaceuticals
ClinicalTrials.gov Identifier: NCT00784264     History of Changes
Other Study ID Numbers: NIS-CHK-DUM-2008/1
First Posted: November 3, 2008    Key Record Dates
Last Update Posted: January 12, 2010
Last Verified: January 2010

Keywords provided by AstraZeneca:
Asymptomatic atherosclerosis
Intima media thickness (IMT)
central obesity
cardiovascular disease

Additional relevant MeSH terms:
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases