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Maternal and Infant Cord Blood Monosaccharide Content

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00783770
First Posted: November 3, 2008
Last Update Posted: May 18, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
United States Department of Agriculture (USDA)
University of Arkansas
Information provided by:
Arkansas Children's Hospital Research Institute
  Purpose

Mother's breast milk provides many benefits to babies with regard to development and improved health. We believe the simple sugars which make up these complex sugars in breast milk and are also found in the brain may be critical to normal brain development in term and preterm infants.

Babies are exposed to these sugars by placental transport during pregnancy and through mother's breast milk after they are born. For the preterm infant, we do not know if breast milk gives enough of these sugars compared to what the baby gets during pregnancy.

A maternal blood sample and blood samples from the baby's umbilical cord will provide us with background information for developing a supplement of special sugars that can be added to infant formulas to provide the amount that the baby usually gets during pregnancy and from breast milk.


Condition
Pregnancy

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Comparison of Monosaccharide Content of Maternal and Umbilical Venous Cord Blood in Term and Preterm Pregnancies

Further study details as provided by Arkansas Children's Hospital Research Institute:

Biospecimen Retention:   Samples Without DNA
plasma will be stored

Enrollment: 48
Study Start Date: July 2005
Primary Completion Date: March 2007 (Final data collection date for primary outcome measure)
Groups/Cohorts
30-33 weeks
mother infant pairs with gestation of 30-33 weeks
34-37 weeks
mother infant pairs with gestation of 34-37 weeks
38-42 weeks
mother infant pairs with gestation of 38-42 weeks

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Twenty-four generally healthy mother-infant pairs.
Criteria

Inclusion Criteria:

  • Healthy mothers with ages ranging from 18 to 35 yrs
  • Delivered infants appropriate weight for gestational age (between 10% and 90%)

Exclusion Criteria:

  • Maternal history of smoking, alcohol or drug use
  Contacts and Locations
No Contacts or Locations Provided
  More Information

Responsible Party: Joanne S. Szabo, M.D., University of Arkansas for Medical Sciences
ClinicalTrials.gov Identifier: NCT00783770     History of Changes
Other Study ID Numbers: 31247
First Submitted: October 31, 2008
First Posted: November 3, 2008
Last Update Posted: May 18, 2011
Last Verified: May 2011

Keywords provided by Arkansas Children's Hospital Research Institute:
Breastfeeding
Infant
Preterm
Nutrition