Striatal and Extra-striatal Mechanisms of Falling in Parkinson's Disease
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT00736671 |
Recruitment Status :
Completed
First Posted : August 18, 2008
Last Update Posted : March 4, 2016
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Condition or disease |
---|
Parkinson's Disease |
Study Type : | Observational |
Actual Enrollment : | 88 participants |
Observational Model: | Case-Control |
Time Perspective: | Prospective |
Official Title: | Striatal and Extra-striatal Mechanisms of Falling in Parkinson's Disease |
Study Start Date : | July 2006 |
Actual Primary Completion Date : | April 2010 |
Actual Study Completion Date : | August 2010 |

Group/Cohort |
---|
Observational Parkinson's Disease
Observational study of subjects with Parkinson disease
|
Observational Normal Control aubjects
Observational study of normal control subjects
|

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 50 Years to 85 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Subjects considered for inclusion will be female or male subjects either currently enrolled or eligible for care at the VA aged 50-85 years, or community volunteers.
- The racial, gender and ethnic characteristics of the proposed subjects population reflect the demographics of the patient population of the VA. However, extra efforts will be made to recruit women and minorities (see table 5).
- Children will be excluded from the study.
- No exclusion criteria shall be based on race, ethnicity, gender, or asymptomatic HIV status.
Exclusion Criteria:
- Inability to stand or walk independently (i.e., patients in Hoehn and Yahr stage IV and V).
- Vertiginous disorder.
- Orthostatic hypotension or unstable cardiovascular disease at risk of syncope (drop in systolic blood pressure of > 20 mm Hg upon standing).
- History of stroke with focal cortical lesions.
- Cerebellar, myelopathic or significant radiculopathy syndrome.
- Diminished light perception in both eyes (< 20/40 corrected OU).
- Intracranial surgery.
- Subjects who have participated in other research protocols such that their cumulative radiation absorbed dose to whole body, gonads, bone marrow or lens of the eye would exceed 5 Rem, or dose to other body organs is more than 15 Rem in preceding 12 months.
- Pregnancy (beta-HCG test within 48 hours of PET study) or breastfeeding.
- Contra-indications to MRI.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00736671
United States, Michigan | |
University of Michigan Functional Neuroimaging, Cognnitive and Mobility Laboratory | |
Ann Arbor, Michigan, United States, 48106 |
Principal Investigator: | Nicolaas Bohnen | VAAAHS |
Responsible Party: | Nicolaas Bohnen, MD, PhD, Principal Investigator, University of Michigan |
ClinicalTrials.gov Identifier: | NCT00736671 |
Other Study ID Numbers: |
HUM00003450 |
First Posted: | August 18, 2008 Key Record Dates |
Last Update Posted: | March 4, 2016 |
Last Verified: | March 2016 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Parkinson Disease Parkinsonian Disorders Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases |
Nervous System Diseases Movement Disorders Synucleinopathies Neurodegenerative Diseases |