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Memory and Picture Viewing Study (MPVS)

This study has been completed.
National Institutes of Health (NIH)
Information provided by (Responsible Party):
Duke University Identifier:
First received: August 13, 2008
Last updated: February 6, 2013
Last verified: January 2013
The purpose of this study is to obtain a database of brain function from a sample of non-smokers while they do tasks in an MRI (magnetic resonance imaging) machine. Our hypothesis is that among nonsmokers, reactivity to smoking cues will be highly similar to control cues but may vary as a function of attitudes toward smoking and/or family history of smoking. We also hypothesize that brain activity during the n-back task will be more similar to data collected during this task when smokers are not abstinent.

Healthy Brain Reactivity of Non-smokers Undergoing fMRI Scanning

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Memory and Picture Viewing Study

Resource links provided by NLM:

Further study details as provided by Duke University:

Primary Outcome Measures:
  • brain reactivity [ Time Frame: 3 weeks ]

Biospecimen Retention:   Samples With DNA
saliva, blood

Enrollment: 116
Study Start Date: July 2008
Study Completion Date: November 2011
Primary Completion Date: November 2011 (Final data collection date for primary outcome measure)

Detailed Description:

Thirty six non-smokers will undergo functional magnetic resonance imaging (fMRI) scanning. During scanning participants will complete the n-back task-a measure of working memory-and the cue-reactivity task-a measure of responses to smoking cues. Before scanning, participants will complete a training session where they will be familiarized with the tasks.

All participants will have to pass a screening visit in order to be included in the study.


Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
generally healthy, right-handed non-smokers, between the ages of 18-55, having smoked less than 50 cigarettes in their lifetime

Inclusion Criteria:

  • generally healthy
  • right-handed non-smokers
  • between the ages of 18-55
  • an expired CO concentration of 5 ppm or less; or a negative urine cotinine test of 100 ng/mL or less (to confirm a non-smoker)
  • having smoked < 50 cigarettes in their lifetime

Exclusion Criteria:

  • inability to attend all sessions
  • significant health problems (hypertension, emphysema, seizure disorder, history of significant heart problems)
  • use of psychoactive medications
  • use of any tobacco or nicotine containing products
  • current alcohol or drug abuse
  • use of illegal drugs as measure by a urine drug screen
  • presence of conditions that would make MRI unsafe (pacemaker, metallic implants
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00736203

United States, North Carolina
Duke University Medical Center
Durham, North Carolina, United States, 27705
Sponsors and Collaborators
Duke University
National Institutes of Health (NIH)
Principal Investigator: Joseph McClernon, PhD Duke University
  More Information

Responsible Party: Duke University Identifier: NCT00736203     History of Changes
Other Study ID Numbers: Pro00008250
Study First Received: August 13, 2008
Last Updated: February 6, 2013

Keywords provided by Duke University:
non-smokers processed this record on July 25, 2017