Diagnostic Value of HS-CRP in Stable Angina.

This study has been completed.
Information provided by:
Shiraz University of Medical Sciences
ClinicalTrials.gov Identifier:
First received: July 18, 2008
Last updated: NA
Last verified: July 2008
History: No changes posted
The aim of this study was to assess the amount of additive value of HS-CRP levels to a positive exercise tolerance test (ETT) in predicting coronary artery disease (CAD) using coronary angiography as the gold standard. The investigators concluded that HS-CRP can be used as a single predictor of coronary vessel involvement in patients with stable angina and positive ETT.

Condition Intervention
Stable Angina
Positive ETT
Procedure: coronary angiography

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Diagnostic
Official Title: Diagnostic Value of HS-CRP in Stable Angina Patients With Positive Exercise Test as Compared With Coronary Angiography.

Resource links provided by NLM:

Further study details as provided by Shiraz University of Medical Sciences:

Primary Outcome Measures:
  • significant coronary lesion [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • severity of CAD [ Designated as safety issue: No ]

Enrollment: 97
Study Start Date: April 2006
Study Completion Date: August 2007
Primary Completion Date: August 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
positive ETT, High HS-CRP
Procedure: coronary angiography
effect of level of HS-CRP
Active Comparator: 2
positive ETT, Low HS-CRP
Procedure: coronary angiography
effect of level of HS-CRP

Detailed Description:
the investigators included 97 patients with positive ETT and stable angina and saw that Hs-CRP is the only predictor of severity of CAD as compared with coronary angiography in stable angina patients.

Ages Eligible for Study:   43 Years to 64 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Stable angina
  • Positive ETT

Exclusion Criteria:

  • Unability to perform ETT
  • Contraindications for ETT and angiography study
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00719992

Iran, Islamic Republic of
Cardiology Ward Shiraz University of Medical Sciences
Shiraz, Fars, Iran, Islamic Republic of, 51318
Sponsors and Collaborators
Shiraz University of Medical Sciences
Study Director: javad kojuri, M.D. Shiraz University of Medical Sciences
  More Information

No publications provided

Responsible Party: Dr Javad Kojuri, Shiraz University of medical sciences
ClinicalTrials.gov Identifier: NCT00719992     History of Changes
Other Study ID Numbers: 4543 
Study First Received: July 18, 2008
Last Updated: July 18, 2008
Health Authority: Iran: Ministry of Health

Keywords provided by Shiraz University of Medical Sciences:
Exercise tolerance test
Coronary angiography

Additional relevant MeSH terms:
Angina Pectoris
Angina, Stable
Cardiovascular Diseases
Chest Pain
Heart Diseases
Myocardial Ischemia
Signs and Symptoms
Vascular Diseases

ClinicalTrials.gov processed this record on February 04, 2016