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Diagnostic Value of HS-CRP in Stable Angina.

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00719992
First Posted: July 22, 2008
Last Update Posted: July 22, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Shiraz University of Medical Sciences
  Purpose
The aim of this study was to assess the amount of additive value of HS-CRP levels to a positive exercise tolerance test (ETT) in predicting coronary artery disease (CAD) using coronary angiography as the gold standard. The investigators concluded that HS-CRP can be used as a single predictor of coronary vessel involvement in patients with stable angina and positive ETT.

Condition Intervention
Stable Angina Positive ETT Procedure: coronary angiography

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Diagnostic
Official Title: Diagnostic Value of HS-CRP in Stable Angina Patients With Positive Exercise Test as Compared With Coronary Angiography.

Resource links provided by NLM:


Further study details as provided by Shiraz University of Medical Sciences:

Primary Outcome Measures:
  • significant coronary lesion

Secondary Outcome Measures:
  • severity of CAD

Enrollment: 97
Study Start Date: April 2006
Study Completion Date: August 2007
Primary Completion Date: August 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
positive ETT, High HS-CRP
Procedure: coronary angiography
effect of level of HS-CRP
Active Comparator: 2
positive ETT, Low HS-CRP
Procedure: coronary angiography
effect of level of HS-CRP

Detailed Description:
the investigators included 97 patients with positive ETT and stable angina and saw that Hs-CRP is the only predictor of severity of CAD as compared with coronary angiography in stable angina patients.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   43 Years to 64 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Stable angina
  • Positive ETT

Exclusion Criteria:

  • Unability to perform ETT
  • Contraindications for ETT and angiography study
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00719992


Locations
Iran, Islamic Republic of
Cardiology Ward Shiraz University of Medical Sciences
Shiraz, Fars, Iran, Islamic Republic of, 51318
Sponsors and Collaborators
Shiraz University of Medical Sciences
Investigators
Study Director: javad kojuri, M.D. Shiraz University of Medical Sciences
  More Information

Responsible Party: Dr Javad Kojuri, Shiraz University of medical sciences
ClinicalTrials.gov Identifier: NCT00719992     History of Changes
Other Study ID Numbers: 4543
First Submitted: July 18, 2008
First Posted: July 22, 2008
Last Update Posted: July 22, 2008
Last Verified: July 2008

Keywords provided by Shiraz University of Medical Sciences:
Exercise tolerance test
HS-CRP
Coronary angiography
Patients

Additional relevant MeSH terms:
Angina Pectoris
Angina, Stable
Chest Pain
Pain
Neurologic Manifestations
Nervous System Diseases
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Signs and Symptoms