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Efficacy of Transference-Focused Psychotherapy for Borderline Personality Disorder

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00714311
Recruitment Status : Completed
First Posted : July 14, 2008
Results First Posted : February 16, 2015
Last Update Posted : February 16, 2015
Information provided by (Responsible Party):
doerings, University Hospital Muenster

Brief Summary:
The purpose of this study is to find out whether Transference-Focused Psychotherapy (TFP) is effective in the treatment of Borderline Personality Disorder.

Condition or disease Intervention/treatment Phase
Borderline Personality Disorder Behavioral: Transference-Focused Psychotherapy Behavioral: treatment by experienced community psychotherapists Not Applicable

Detailed Description:

Borderline personality disorder represents a sever clinical condition that affects 1-2% of the community and is characterized by a pervasive instability of interpersonal relationships, self-image, and affects, as well as a marked impulsivity; up to 10% of the patients commit suicide.

Transference-Focused Psychotherapy (TFP) is one psychotherapeutic approach among five that have been manualized and evaluated in RCTs. So far, TFP has not been compared to a control condition which is a crucial step in the evaluation of the efficacy of a psychosocial intervention.

This study is an RCT that compares one year of outpatient TFP to treatment by experienced community psychotherapists for borderline personality disorder.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 104 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Randomized-Controlled Trial of Transference-Focused Psychotherapy vs. Treatment by Experienced Community Psychotherapists for Borderline Personality Disorder
Study Start Date : October 2004
Actual Primary Completion Date : February 2009
Actual Study Completion Date : February 2015

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Active Comparator: TFP
Transference-Focused Psychotherapy
Behavioral: Transference-Focused Psychotherapy
Outpatient psychotherapy according to the treatment manual, sessions of 50 minutes twice per week

Active Comparator: ECP
treatment by experienced community psychotherapists
Behavioral: treatment by experienced community psychotherapists
Outpatient psychotherapy in private practices or outpatient units of psychiatric hospitals. Licensed psychotherapists with experience and special interest in the treatment of borderline patients are treating according to the method they have learned.

Primary Outcome Measures :
  1. Drop-out [ Time Frame: 1 year ]
    Did not finish one year of treatment.

  2. Suicidality (Suicide Attempts) [ Time Frame: 1 year ]

Secondary Outcome Measures :
  1. Psychosocial Functioning (Global Assessment of Functioning, GAF-Score) [ Time Frame: 1 year ]
  2. Level of Personality Organization (Structured Interview for Personality Organization, STIPO) [ Time Frame: 1 year ]
  3. Number of Self-harming Acts [ Time Frame: 1 year ]
  4. Self-assessment of Psychopathology (BDI, STAI, BSI) [ Time Frame: 1 year ]
  5. Attachment Style and Reflective Function (Adult Attachment Interview, AAI) [ Time Frame: 1 year ]
  6. Borderline Symptomatology (DSM-IV Criteria) [ Time Frame: 1 month ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Written informed consent to the participation in the study
  • Diagnosis of BPD according to DSM-IV as assessed using the SCID-II
  • Age between 18 and 45 years
  • Sufficient knowledge of the German language

Exclusion Criteria:

  • Diagnosis of schizophrenia, bipolar disorder, severe substance abuse, organic pathology, or mental retardation according to DSM-IV as assessed using the SCID-I
  • Diagnosis of antisocial personality disorder according to DSM-IV as assessed using the SCID-II

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00714311

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Dept. of Psychoanalysis and Psychotherapy, Medical University Vienna
Vienna, Austria, 1090
Dept. of Psychiatry, Technical University of Munich
Munich, Bavaria, Germany, 81675
Sponsors and Collaborators
University Hospital Muenster
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Principal Investigator: Stephan Doering, MD University of Muenster, Germany
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: doerings, Univ.-Prof. Dr. med., University Hospital Muenster Identifier: NCT00714311    
Other Study ID Numbers: 1106/04
First Posted: July 14, 2008    Key Record Dates
Results First Posted: February 16, 2015
Last Update Posted: February 16, 2015
Last Verified: February 2015
Keywords provided by doerings, University Hospital Muenster:
borderline personality disorder
randomized controlled trial
Transference-Focused Psychotherapy
treatment by experienced community psychotherapists
Additional relevant MeSH terms:
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Personality Disorders
Borderline Personality Disorder
Pathologic Processes
Mental Disorders