Incidence of Oral Candidiasis, Prevalence of C. Dubliniensis in HIV Patients and In-vitro Azole Susceptibility (ICONIC)
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ClinicalTrials.gov Identifier: NCT00692783 |
Recruitment Status
:
Terminated
(Dr. Vindas completed his fellowship + low enrollment)
First Posted
: June 6, 2008
Last Update Posted
: May 8, 2015
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Condition or disease |
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Candidiasis HIV Infections |
This is a study to try to establish the prevalence of C. dubliniensis as a causative organism of OPC in HIV and/or AIDS patients. We will aim to establish the resistance pattern for azoles but also for Flucytosine and amphotericin of these isolates.
This study will serve as a support to previously published articles that have suggested intrinsic azole-resistance within this particular species of candida and we will try to postulate its possible correlation with clinical failure.
Study Type : | Observational |
Actual Enrollment : | 10 participants |
Time Perspective: | Prospective |
Official Title: | Incidence of Oral Candidiasis, Prevalence of Candida Dubliniensis in HIV Patients and In-vitro Azole Susceptibility. (I.C.O.N.I.C.) |
Study Start Date : | May 2008 |
Actual Primary Completion Date : | October 2008 |
Actual Study Completion Date : | January 2009 |
- Incidence of oropharyngeal candidiasis in our HIV population; estimation of the prevalence of candida dubliniensis and pattern of azole resistance to direct future treatment [ Time Frame: April 2009 ]

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Ages Eligible for Study: | 18 Years to 65 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Any patient 18 years old or older with a documented diagnosis of HIV infection with or without AIDS-defining illnesses at the time of assessment, who is presenting with clinical symptoms and physical findings compatible with oropharyngeal candidiasis (as defined by the IDSA Guidelines for the Treatment and Management of HIV and HIV- related complications.
Exclusion Criteria:
- Any prior diagnosis or established treatment for oropharyngeal, mucocutaneous or esophageal candidiasis documented in the patient's chart or any proven diagnosis based on reviews of physically available medical records and or history provided by patients that can be subject to later confirmation pertaining to the use of parenteral antifungals within 6 months prior to enrollment (azoles, echinocandins, amphotericin B, Flucytosine, etc).

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00692783
United States, Florida | |
Duval County Department of Health. Boulevard Comprehensive Care Center | |
Jacksonville, Florida, United States, 32206 |
Principal Investigator: | Jose Vindas, MD | University of Florida |
Publications of Results:
Responsible Party: | University of Florida |
ClinicalTrials.gov Identifier: | NCT00692783 History of Changes |
Other Study ID Numbers: |
UFJ2008-19 |
First Posted: | June 6, 2008 Key Record Dates |
Last Update Posted: | May 8, 2015 |
Last Verified: | May 2015 |
Keywords provided by University of Florida:
candida dubliniensis candidiasis |
HIV AIDS azole resistance. |
Additional relevant MeSH terms:
HIV Infections Candidiasis Disease Susceptibility Candidiasis, Oral Lentivirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases Sexually Transmitted Diseases, Viral |
Sexually Transmitted Diseases Immunologic Deficiency Syndromes Immune System Diseases Mycoses Disease Attributes Pathologic Processes Mouth Diseases Stomatognathic Diseases |