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Lenalidomide, Rituximab, and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Diffuse Large Cell or Follicular B-Cell Lymphoma

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00670358
Recruitment Status : Active, not recruiting
First Posted : May 1, 2008
Last Update Posted : January 11, 2022
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Mayo Clinic

Brief Summary:

RATIONALE: Lenalidomide may stimulate the immune system in different ways and stop cancer cells from growing. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin, vincristine, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving lenalidomide together with rituximab and combination chemotherapy may kill more cancer cells.

PURPOSE: This phase I/II trial is studying the side effects and best dose of lenalidomide when given together with rituximab and combination chemotherapy and to see how well they work in treating patients with newly diagnosed stage II, stage III, or stage IV diffuse large cell or follicular B-cell lymphoma.

Condition or disease Intervention/treatment Phase
Lymphoma Biological: pegfilgrastim Biological: rituximab Drug: cyclophosphamide Drug: doxorubicin hydrochloride Drug: lenalidomide Drug: prednisone Drug: vincristine sulfate Genetic: polymorphism analysis Other: laboratory biomarker analysis Phase 1 Phase 2

Detailed Description:



  • To determine the maximum tolerated dose of lenalidomide when given in combination with rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone in patients with newly diagnosed stage II-IV diffuse large cell or grade 3 follicular B-cell lymphoma. (Phase I)
  • To assess the efficacy of this regimen, in terms of event-free survival and response rate, in these patients. (Phase II)
  • To assess the safety of this regimen in these patients. (Phase II)


  • To assess the host immune function at baseline and after treatment and correlate these parameters with tumor response and event-free survival.

OUTLINE: This is a multicenter, phase I dose-escalation study of lenalidomide followed by a phase II study.

  • Phase I: Patients receive rituximab IV, cyclophosphamide IV, doxorubicin hydrochloride IV, and vincristine IV on day 1, oral prednisone on days 1-5, and oral lenalidomide on days 1-10. Patients also receive pegfilgrastim subcutaneously on day 2. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity.
  • Phase II: Patients receive lenalidomide at the maximum tolerated dose determined in phase I and rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, prednisone, and pegfilgrastim as in phase I.

Blood is collected at baseline, before course 3, and after completion of study treatment for translational research studies. Research studies include immune function and cytokine analysis, T- and B- quantitative lymphocyte analysis, and single nucleotide polymorphism analysis.

After completion of study therapy, patients are followed every 3 months for 1 year, every 4 months for 1 year, and then every 6 months for 3 years.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 24 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Phase I/II Study of Lenalidomide (Revlimid), Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisone (R2CHOP) Chemoimmunotherapy in Patients With Newly Diagnosed Diffuse Large Cell and Follicular Grade IIIA/B B Cell Lymphoma
Actual Study Start Date : August 25, 2008
Actual Primary Completion Date : May 7, 2021
Estimated Study Completion Date : December 31, 2022

Primary Outcome Measures :
  1. Toxicity as assessed by NCI CTCAE v3.0 (Phase I)
  2. Event-free survival at 12 months (Phase II)

Secondary Outcome Measures :
  1. Overall response rate
  2. Overall complete response rate
  3. Event-free survival
  4. Overall survival
  5. Progression-free survival
  6. Duration of response
  7. Immune function before and after treatment as assessed by T-, B-, and NK-cell quantification
  8. Correlation of immune function with clinical outcomes

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years to 120 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No


  • Histologically confirmed diffuse large cell or grade 3A/B follicular lymphoma

    • Newly diagnosed disease
    • Stage II, III, or IV disease
  • Measurable disease, defined as ≥ 1 lesion ≥ 1.5 cm in one diameter, as detected by CT scan or PET-CT scan (PET/CT fusion)
  • CD20-positive disease
  • No post-transplant lymphoproliferative disorder (PTLD)
  • No CNS lymphoma or cerebrospinal fluid involvement with malignant lymphoma cells


  • ECOG performance status 0-2
  • ANC ≥ 1,500/mm³
  • Platelet count ≥ 100,000/mm³
  • Total bilirubin ≤ 1.5 times upper limit of normal (ULN) OR direct bilirubin normal
  • Alkaline phosphatase ≤ 3 times ULN (5 times ULN if direct liver involvement by lymphoma)
  • AST ≤ 3 times ULN (5 times ULN if direct liver involvement by lymphoma)
  • Creatinine ≤ 2 times ULN
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile female patients must use effective double-method contraception for ≥ 28 days before, during, and for ≥ 28 days after completion of study therapy
  • Fertile male patients must use effective contraception during and for ≥ 28 days after completion of study therapy, even if they have had a successful vasectomy
  • No blood, sperm, or semen donation during and for ≥ 28 days after completion of study therapy
  • Willing to return to enrolling institution for follow-up
  • Willing to provide blood samples for translational research purposes
  • No comorbid systemic illness or other severe concurrent disease that, in the judgment of the investigator, would preclude study entry or significantly interfere with the proper assessment of safety and toxicity of the prescribed study regimen
  • No known HIV positivity
  • Not immunocompromised
  • No concurrent uncontrolled illness including, but not limited to, any of the following:

    • Ongoing or active infection
    • Symptomatic congestive heart failure
    • Unstable angina pectoris
    • Cardiac arrhythmia
    • Psychiatric illness/social situation that would preclude compliance with study requirements
  • No other active malignancy, except localized nonmelanotic skin cancer or any cancer that, in the judgment of the investigator, has been treated with curative intent and will not interfere with the study treatment plan and response assessment
  • No myocardial infarction within the past 6 months
  • No congestive heart failure requiring ongoing maintenance therapy for life-threatening ventricular arrhythmias
  • Ejection fraction ≥ 45% by MUGA or ECHO
  • No history of life threatening or recurrent thrombosis/embolism (unless on anticoagulation therapy during study treatment)


  • No prior radiotherapy to ≥ 25% of the bone marrow
  • No concurrent erythroid-stimulating agents (e.g., Procrit, Aranesp)
  • No other concurrent treatment for lymphoma
  • No concurrent radiotherapy, chemotherapy, or immunotherapy for another active malignancy
  • Able to receive concurrent prophylactic anticoagulation therapy (e.g., low-dose aspirin [81 mg] daily or an alternative prophylaxis [e.g., warfarin or low molecular weight heparin])

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00670358

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United States, Arizona
Mayo Clinic in Arizona
Scottsdale, Arizona, United States, 85259-5499
United States, Florida
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224
United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
Sponsors and Collaborators
Mayo Clinic
National Cancer Institute (NCI)
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Study Chair: Grzegorz S. Nowakowski, M.D. Mayo Clinic
Principal Investigator: Craig B. Reeder, M.D. Mayo Clinic
Principal Investigator: Candido E. Rivera, M.D. Mayo Clinic
Study Chair: Judy Olmos, R.N. Mayo Clinic
Study Chair: Michele Maharaj, R.N. Mayo Clinic
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Mayo Clinic Identifier: NCT00670358    
Other Study ID Numbers: MC078E
P30CA015083 ( U.S. NIH Grant/Contract )
MC078E ( Other Identifier: Mayo Clinic Cancer Center )
RV-NHL-PI-0325 ( Other Identifier: Celgene Protocol )
07-007992 ( Other Identifier: Mayo Clinic IRB )
NCI-2009-01196 ( Registry Identifier: NCI CTRP )
First Posted: May 1, 2008    Key Record Dates
Last Update Posted: January 11, 2022
Last Verified: January 2022
Keywords provided by Mayo Clinic:
contiguous stage II adult diffuse large cell lymphoma
noncontiguous stage II adult diffuse large cell lymphoma
stage III adult diffuse large cell lymphoma
stage IV adult diffuse large cell lymphoma
contiguous stage II grade 3 follicular lymphoma
noncontiguous stage II grade 3 follicular lymphoma
stage III grade 3 follicular lymphoma
stage IV grade 3 follicular lymphoma
Additional relevant MeSH terms:
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Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Liposomal doxorubicin
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Antirheumatic Agents
Antineoplastic Agents, Alkylating
Alkylating Agents
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Myeloablative Agonists
Antineoplastic Agents, Immunological
Antibiotics, Antineoplastic
Topoisomerase II Inhibitors
Topoisomerase Inhibitors
Enzyme Inhibitors
Anti-Inflammatory Agents