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Topical Therapy With Cooling Effect in Dry Itchy Skin

This study has been completed.
Information provided by:
University Hospital Muenster Identifier:
First received: April 22, 2008
Last updated: February 1, 2010
Last verified: February 2010
Dry skin is a physiological condition and is characterized in contrast to greasy skin by roughness, desquamation and lack of brightness of the skin surface. Subjectively, feelings of tension, burning and itching can occur. The skin reacts more intensive on external and physical noxae. Dry skin is caused by a lack of moisture. This is most common during the winter months, when heating systems dry the air. Bathing with hot water, spending extended periods of time in the hot sun, and the skin's natural aging process also remove moisture and oils from the skin. It is diagnosed through clinical observation. People suffering from dry skin often desire to improve this condition for optical cosmetic reasons and due to the occasional feeling of tension. The aim of this investigation is to observe the improvement (or not) of dry itchy skin by a lotion containing a cooling compound

Condition Intervention
Compensate the Roughness of the Skin Compensate the Sensory Symptoms Device: cooling compound (ph5 Eucerin)

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Prevention
Official Title: kühlender Effekt Der Eucerin pH5 Lotion Und Der Eucerin pH5 Lotion Mit Cooling Compound Bei Trockener, Juckender Haut

Resource links provided by NLM:

Further study details as provided by University Hospital Muenster:

Primary Outcome Measures:
  • Compensate the roughness of the skin Compensate sensory symptoms [ Time Frame: 4 weeks ]

Estimated Enrollment: 70
Study Start Date: April 2008
Study Completion Date: February 2010
Primary Completion Date: February 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: 1
ph5 Eucerin Lotion with cooling compound
Device: cooling compound (ph5 Eucerin)
application twice daily to the skin
Other Name: ph5 Eucerin
Placebo Comparator: 2
ph5 Eucerin Lotion
Device: cooling compound (ph5 Eucerin)
application twice daily to the skin
Other Name: ph5 Eucerin

Detailed Description:
The patient use the lotion twice daily for a four-week period. Additionally, the patient receives a documentation sheets to note several parameters. In a sensory assessment, product specific parameter such as spreadability, permeability, lubricating, smell of lotion and cosmetic acceptance during the treatment will be assessed (at the beginning, after 2 weeks, after 4 weeks, 2 weeks after stopping treatment). Before and after skin care measurement, the skin surface will be investigated by d-squames and corneometer. After four weeks the skin care measurement will be terminated and the patient can continue with a treatment of his choice. A monitoring of at least 70 patients is intended.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  1. Patients age: over 18 years
  2. itch over VAS 3

Exclusion Criteria:

  1. pregnancy, lactating women
  2. drug abuse
  3. active psychosomatic and psychiatric disease
  4. active cancer.
  5. topical application of tacrolimus, pimecrolimus, corticosteroids or capsaicin two weeks before study start
  6. intake of antihistamines, corticosteroids, cyclosporine A and other immunosuppressants, naltrexone, UV-therapy two weeks before study start
  7. participation in any other research study during the previous 4 weeks.
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Please refer to this study by its identifier: NCT00669708

Department of Dermatology, University of Münster
Münster, Germany, 48149
Sponsors and Collaborators
University Hospital Muenster
Principal Investigator: Sonja Ständer, MD Department of Dermatology, University of Münster
  More Information

Responsible Party: Prof. Dr. Sonja Ständer, Department of Dermatology Identifier: NCT00669708     History of Changes
Other Study ID Numbers: SST-Pr-12-2007
Study First Received: April 22, 2008
Last Updated: February 1, 2010

Keywords provided by University Hospital Muenster:
dry skin
itch processed this record on August 23, 2017