Intracardiac T-wave Alternans and Ischemia
T-wave alternans is a test that looks at microvolt changes in the T-wave on a beat to beat basis. The presence or absence of such changes has been shown to predict or exclude future arrhythmic events. The mechanism of T-wave alternans is unclear, but may relate to calcium metabolism in the heart, and may be affected by conditions such as ischemia or heart failure.
The purpose of this study is to determine whether T-wave alternans, as measured through the lead of an implantable defibrillator, is produced by acute ischemia induced by occlusion during percutaneous coronary interventions.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Intracardiac T-wave Alternans and Ischemia During Percutaneous Coronary Interventions|
- Number of Subjects With Positive T Wave Studies During a Coronary Intervention [ Time Frame: During the coronary intervention, upto 2 hours ] [ Designated as safety issue: No ]Positive T wave alternans is determined by a proprietary program using ECG recordings during a stress test. The result is reported as positive, negative, or indeterminate.
|Study Start Date:||August 2008|
|Study Completion Date:||July 2012|
|Primary Completion Date:||July 2012 (Final data collection date for primary outcome measure)|
Patients undergoing a percutaneous coronary intervention (PCI) with an implanted Medtronic defibrillator with the capability of telemetry of the intracardiac signal.
Procedure: Percutaneous coronary intervention
PCI previously electively scheduled.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00669552
|United States, New York|
|Columbia University Medical Center|
|New York, New York, United States, 10032|
|Principal Investigator:||Jose M Dizon, MD||Columbia University|