The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity
Clinically, iodinated contrast-medium (CM) is widely used in angiography and computerized tomography. CM-induced nephropathy (CMIN) is one major complication after application of CM. Therefore, how to prevent CMIN is always one of the hot topics concerned by nephrologists, cardiologists, and radiologists.
The present study is aimed to determine the norepinephrine concentration, oxidative markers, and tubular damage markers in the urine samples of patients undergoing intravenous pyelography (IVP).
The working hypothesis is high-osmolarity contrast media (HOCM) causes more oxidative stress and greater tubular damage than iso-osmolarity contrast media (IOCM).
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity|
The urine samples are collected just before and 30 minutes after IVP.The samples are immediately frozen at -80'C until analyzed.
|Study Start Date:||December 2007|
|Primary Completion Date:||January 2008 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00632892
|Far Eastern Memorial Hospital|
|Pan Chiao, Taipei, Taiwan, 220|