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Lithium Dilution Method in Guiding Fluid Therapy in Critically Ill Patients (LIGA)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2008 by ASQA a.s..
Recruitment status was:  Recruiting
Information provided by:
ASQA a.s. Identifier:
First received: February 21, 2008
Last updated: February 28, 2008
Last verified: February 2008
Hypothesis: Fluid management guided by LiDCO doesn´t increase cumulative fluid balance and shorten organ dysfunction compared to fluid management based on CVP and clinical judgment.

Condition Intervention
Critical Illness
Device: LiDCO technology

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Health Services Research
Official Title: LIGA Trial-Lithium Dilution Method in Guiding Fluid Therapy in Critically Ill Patients

Further study details as provided by ASQA a.s.:

Primary Outcome Measures:
  • positive or negative fluid balance [ Time Frame: one year ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • effect of LiDCO monitoring on cumulative fluid balance [ Time Frame: one year ] [ Designated as safety issue: No ]

Estimated Enrollment: 15
Study Start Date: January 2008
Estimated Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: LI
arm controled by LIDCO technology
Device: LiDCO technology
non invasive monitoring of cardiac output
No Intervention: CA
standard approach


Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Age
  • Needs for fluid chalange
  • Invasive ventilatory supportinvasive blood pressure monitoring
  • Lidco monitoring
  • Central venous catheter

Exclusion Criteria:

  • DNR
  • Need for CRRT
  • Head injury
  Contacts and Locations
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Please refer to this study by its identifier: NCT00626756

Czech Republic
ASQA a.s.
Prague, Czech Republic, 106 00
Sponsors and Collaborators
ASQA a.s.
Principal Investigator: Vladimir Cerny, MD, PhD, FCCM University Hospital Hradec Kralove
  More Information

Responsible Party: Pavel Valek M.D., ASQA a.s. Identifier: NCT00626756     History of Changes
Other Study ID Numbers: LigaStudy  LIGA2008 
Study First Received: February 21, 2008
Last Updated: February 28, 2008
Health Authority: Czech Republic: State Institute for Drug Control

Keywords provided by ASQA a.s.:
Lidco technology
guided therapy
fluid management guided by Lidco technology

Additional relevant MeSH terms:
Critical Illness
Disease Attributes
Pathologic Processes processed this record on December 02, 2016