Roflumilast In-Vitro Basophil Release
This study is looking for allergic asthmatics. Lung and allergy testing will be done to verify. If qualified, blood will be drawn for laboratory studies.
|Study Design:||Time Perspective: Prospective|
|Official Title:||Effect of Roflumilast In-Vitro on Basophil Histamine, Leukotriene, IL-4 and IL13-release.|
Polymorphal Blood Mononuclar Cells will be stimulated to release various cytokines. The supernatant of the stimulations will be stored for batched analysis.
|Study Start Date:||August 2007|
|Study Completion Date:||January 2010|
|Primary Completion Date:||January 2010 (Final data collection date for primary outcome measure)|
Non-smoking allergic asthmatics will be verified using pulmonary function, skin prick testing, exhaled nitric oxide and serum IgE. If qualified, blood will be drawn, treated with study medication and then stimulated with the allergen to which the subject is allergic. Mediators including Histamine, IL-13, IL-4, and leukotrienes will be measured.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00613587
|United States, Nebraska|
|Creighton University Medical Center|
|Omaha, Nebraska, United States, 68131|
|Principal Investigator:||Robert G Townley, MD||Creighton University|