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Study of Tai Chi Exercise and Balance in Persons With Parkinson's Disease

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00611481
First Posted: February 11, 2008
Last Update Posted: October 12, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Institute of Neurological Disorders and Stroke (NINDS)
Information provided by (Responsible Party):
Oregon Research Institute
  Purpose
Patients practicing Tai Chi will exhibit significant improvements in primary outcome measures of balance, and secondary outcomes of gait, physical performance, Unified Parkinson's Disease Rating Scale, Falls, muscle strength.

Condition Intervention Phase
Parkinson's Disease Behavioral: Tai Chi Behavioral: Strength training Behavioral: Low-Impact Exercise Control Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Phase II Study of Tai Chi Exercise in Relation to Balance in Persons With Parkinson's Disease

Resource links provided by NLM:


Further study details as provided by Oregon Research Institute:

Primary Outcome Measures:
  • Balance [ Time Frame: 3 time points ]

Secondary Outcome Measures:
  • gait, physical performance, Unified Parkinson's Disease Rating Scale, falls, Muscle strength [ Time Frame: 3 time points ]

Enrollment: 195
Study Start Date: October 2008
Study Completion Date: August 2011
Primary Completion Date: May 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Tai Chi Behavioral: Tai Chi
a set of pre-designed Tai Chi Movements
Active Comparator: B. Strength training Behavioral: Strength training
Lower-extremity strength training exercises
C. Low-Impact Behavioral: Low-Impact Exercise Control
a set of chair-based low-impact exercises

Detailed Description:
The study is designed to determine the effects of Tai Chi training on balance and other functional outcomes in persons with Parkinson's disease.
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   40 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

Patients who have:

  • A diagnosis of idiopathic PD, with a disease severity rating of stage I to IV on the Hoehn and Yahr scale (Hoehn & Yahr, 1967)
  • At least 1 score of 2 or more for at least 1 limb for either the tremor, rigidity, or bradykinesia item of the Unified Parkinson's Disease Rating Scale (UPDRS)
  • Stable medication usage
  • Not participated in a structured exercise program (i.e., not involved in any routine, organized physical activity program lasting 30 minutes or more per day, such as a gym program or regularly scheduled instructor-led exercise class) in the previous 2 months
  • Ability to stand unaided or walk independently; had a personal physician's or neurologist's clearance for participation; and had a willingness to be assigned to intervention conditions.

Exclusion Criteria:

Patients who:

  • Participate in any other behavioral or pharmacological research study
  • Have cognitive decline (Mini-Mental State Examination score, ≤ 24) (Folstein et al., 1975)
  • Have self-reported diagnosis of Alzheimer disease or other severe neurological (stage III and IV PD)
  • Have evidence of progressive or debilitating conditions (metastatic cancer, severe heart or lung disease, crippling arthritis) or severe losses in vision and hearing that would limit their tolerance to testing and training procedures, that would interfere with study participation
  • Are unavailable during the study period.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00611481


Locations
United States, Oregon
Oregon Research Institute
Eugene, Oregon, United States, 97403
Sponsors and Collaborators
Oregon Research Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Investigators
Principal Investigator: Fuzhong Li, Ph.D. Oregon Research Institute
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Oregon Research Institute
ClinicalTrials.gov Identifier: NCT00611481     History of Changes
Other Study ID Numbers: R01NS047130 ( U.S. NIH Grant/Contract )
NS047130
First Submitted: February 6, 2008
First Posted: February 11, 2008
Last Update Posted: October 12, 2011
Last Verified: October 2011

Additional relevant MeSH terms:
Parkinson Disease
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases


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