Mindfulness Meditation Training in HIV (MBSR)
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ClinicalTrials.gov Identifier: NCT00600561 |
Recruitment Status :
Completed
First Posted : January 25, 2008
Last Update Posted : January 25, 2008
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Condition or disease | Intervention/treatment | Phase |
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HIV Infections | Behavioral: MBSR | Phase 2 |
Mindfulness meditation, which is described as a process of bringing awareness to moment-to-moment experience, has been receiving substantial scientific attention as a process that can be stress and health protective (Brown, Ryan, & Creswell, 2007). Recent reviews by Baer (2003), Bishop (2002), and Grossman et al (2004) support the effectiveness of the standardized and manualized MBSR program in reducing stress and functional disability in a variety of chronic illnesses, although no studies have tested if MBSR impacts clinical markers of HIV, although some evidence suggests that MBSR improves some markers of innate immunity and quality of life in HIV-infected adults (see Robinson, Mathews, & Witek-Janusek, 2003). In this study, we propose to extend this work by investigating the impact of this intervention on biological and functional health status in HIV-positive adults.
We propose to determine whether the 8-week MBSR program is more effective than a one-day MBSR seminar in: (1) maintaining immune resistance in HIV infection (i.e. maintaining counts of CD4+ T lymphocytes and reducing HIV viral load), and (2) improving HIV-related quality of life. Additional analyses will test for a dose-response effect of MBSR by examining if MBSR class attendance and daily meditation practice are associated with the primary and secondary outcomes. These aims will be tested in a sample of 50 HIV-positive adults that is diverse with respect to ethnicity, gender and sexual orientation.
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 50 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Single (Outcomes Assessor) |
Primary Purpose: | Treatment |
Official Title: | Biobehavioral Effects of Mindfulness-Based Stress Reduction in HIV |
Study Start Date : | June 2005 |
Actual Primary Completion Date : | December 2007 |
Actual Study Completion Date : | January 2008 |
Arm | Intervention/treatment |
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Active Comparator: 1-Day MBSR
One-day condensed MBSR class
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Behavioral: MBSR
Mindfulness-Based Stress Reduction Intervention
Other Names:
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Experimental: 8-week MBSR
8-week Mindfulness-Based Stress Reduction Intervention
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Behavioral: MBSR
Mindfulness-Based Stress Reduction Intervention
Other Names:
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- CD4+ T lymphocytes (counts) [ Time Frame: Pre-test and post-test ]
- HIV-related Quality of Life [ Time Frame: Pre-test and post-test ]
- HIV viral load [ Time Frame: Pre-test and post-test ]

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Diagnosed HIV for > 6 months
- English speaking
- 18 years old or older
- Indicate some distress (>4 on the Patient Health Questionnaire-9)
- Willing to be randomized
Exclusion Criteria:
- Any substance abuse or treatment for a psychiatric disorder in the past 30 days
- Currently diagnosed with AIDS or had CD4+ T lymphocytes <200 cells
- Hepatitis (A, B, or C)
- Indicate a regular mind-body practice (e.g., yoga, meditation) in the past six months

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00600561
United States, California | |
Cousins Center for Psychoneuroimmunology, UCLA | |
Los Angeles, California, United States, 90095 |
Principal Investigator: | Hector F Myers, PhD | UCLA Department of Psychology | |
Study Director: | J. David Creswell, PhD | Cousins Center for Psychoneuroimmunology, UCLA |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Hector F. Myers, PhD, UCLA Department of Psychology |
ClinicalTrials.gov Identifier: | NCT00600561 |
Other Study ID Numbers: |
MBSR-HIV-Trial-Seedgrant M01RR000865 ( U.S. NIH Grant/Contract ) |
First Posted: | January 25, 2008 Key Record Dates |
Last Update Posted: | January 25, 2008 |
Last Verified: | January 2008 |
meditation mindfulness HIV CD4 Complementary Therapies |
HIV Infections Lentivirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases |
Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Immunologic Deficiency Syndromes Immune System Diseases |