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AIDS and Cancer Specimen Bank (ACSB)

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ClinicalTrials.gov Identifier: NCT00587912
Recruitment Status : Completed
First Posted : January 8, 2008
Last Update Posted : April 21, 2011
Sponsor:
Collaborators:
National Cancer Institute (NCI)
George Washington University
University of Hawaii
University of California, San Francisco
Kaiser Permanente
Information provided by:
Memorial Sloan Kettering Cancer Center

Study Description
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information
Brief Summary:

The purpose of this study is to obtain clinical specimens from pathologists and physicians involved in the diagnosis and care of patients with AIDS and non-AIDS associated malignancies.

The National Cancer Institute has set up a Bank for tissues and biological fluids from HIVpositive and HIV-negative individuals in order to have specimens available for scientists studying malignancies associated with HIV disease.


Condition or disease
Kaposi's Sarcoma AIDS Related Kaposi's Sarcoma Classical Non-Hodgkin's Lymphoma HEMATOPOIETIC SYSTEM Cancer AIDS

Detailed Description:
The overall goal of the AIDS and Cancer Specimen Bank is to obtain clinical specimens from pathologists and physicians involved in the diagnosis and care of patients with AIDS and non- AIDS associated malignancies. These specimens will be banked and linked to a clinical data set so that experimental results obtained by analysis of specific specimens can be linked to relevant clinical data. Contents of the ACSB will be made available to researchers through an application to the National Cancer Institute. Strict patient confidentiality protection guidelines are in place for all specimens in the ACSB. The objective of this protocol is to obtain clinical specimens from potential participants in clinical trials conducted by the AIDS Malignancies Consortium, and from other patients with and without HIV infection, who have AIDS-Associated malignancies.

Study Design
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Study Type : Observational
Actual Enrollment : 65 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: AIDS and Cancer Specimen Bank (ACSB)
Study Start Date : June 1997
Actual Primary Completion Date : April 2011
Actual Study Completion Date : April 2011

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Groups and Cohorts
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information


Outcome Measures
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Primary Outcome Measures :
  1. Identify and improve access to tumor tissue, biological specimens, and associated clinical outcome data that could be utilized for research by the research community at-large on the pathogenesis of HIV and non-HIV associated malignancies. [ Time Frame: 3 years ]

Biospecimen Retention:   Samples With DNA
Blood, urine, other bodily fluids (eg, pleural fluid), and tumor tissue obtained from patients.

Eligibility Criteria
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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The Source of specimens will include patients screened for participation on protocols conducted by the AIDS Malignancy Consortium, as well as other patients with HIV infection and cancer who are not eligible for participation in AMC trials, and patients without HIV who have malignancies associated with HIV or with immunosuppression.
Criteria

Inclusion Criteria:

  • Patient > 18 years of age
  • Suspected or confirmed AIDS-Associated malignancy with or without HIV infection
  • Will obtain fresh tissue and/or biological fluids
  • Patient signed the correct version of the informed consent

Exclusion Criteria:

Contacts and Locations
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00587912


Locations
United States, New York
Memorial Sloan-Kettering Cancer Center
New York, New York, United States, 10065
Sponsors and Collaborators
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)
George Washington University
University of Hawaii
University of California, San Francisco
Kaiser Permanente
Investigators
Principal Investigator: David Straus, MD Memorial Sloan Kettering Cancer Center
More Information
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Additional Information:
Memorial Sloan-Kettering web site  This link exits the ClinicalTrials.gov site

Responsible Party: David Straus, MD, Memorial Sloan-Kettering Cancer Center
ClinicalTrials.gov Identifier: NCT00587912     History of Changes
Other Study ID Numbers: 97-043
First Posted: January 8, 2008    Key Record Dates
Last Update Posted: April 21, 2011
Last Verified: April 2011

Keywords provided by Memorial Sloan Kettering Cancer Center:
Kaposi's Sarcoma AIDS Related
Kaposi's Sarcoma Classical
Non-Hodgkin's Lymphoma
 HEMATOPOIETIC SYSTEM
Cancer
AIDS

Additional relevant MeSH terms:
Sarcoma
Lymphoma, Non-Hodgkin
Sarcoma, Kaposi
AIDS-Related Opportunistic Infections
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Neoplasms
Lymphoma
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
 Herpesviridae Infections
DNA Virus Infections
Virus Diseases
Neoplasms, Vascular Tissue
Opportunistic Infections
Infection
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Parasitic Diseases
Immunologic Deficiency Syndromes