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Nasal Epithelium Gene Expression Profiling in Child Respiratory Allergic Disease

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00569361
First Posted: December 7, 2007
Last Update Posted: June 9, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
ADPHUN, FRM
Information provided by:
Centre Hospitalier Universitaire de Nice
  Purpose

Using a human pangenomic microarray, the researchers established expression profiles of nasal epithelial cells, collected by brushing of patients belonging to one of four distinct groups:

  1. allergic rhinitis to dust mite (AR) isolated (n=12),
  2. AR associated with bronchial hyperreactivity (n=12),
  3. AR associated with asthma (n=14),
  4. control (n=14).

Condition Intervention
Allergic Rhinitis Procedure: Collection of nasal epithelial cells

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Screening
Official Title: Nasal Epithelium Gene Expression Profiling in Child Respiratory Allergic

Resource links provided by NLM:


Further study details as provided by Centre Hospitalier Universitaire de Nice:

Primary Outcome Measures:
  • Transcriptome analysis: genes statistically modulated between groups, predictive biomarkers allowing correct classification of groups [ Time Frame: At the sample time ]

Secondary Outcome Measures:
  • Validation with other techniques: Q-PCR [ Time Frame: At the sample time ]

Enrollment: 80
Study Start Date: November 2004
Study Completion Date: October 2005
Arms Assigned Interventions
A
Collection of nasal epithelial cells by brushing
Procedure: Collection of nasal epithelial cells
Collection of nasal epithelial cells by brushing

Detailed Description:

Context: Asthma is the most frequent chronic disease in childhood. Allergic rhinitis has been described as a risk factor to develop asthma. The objective of the study was to evaluate the contribution of the respiratory epithelium to development of allergic rhinitis and asthma and to identify the molecular mechanisms driving rhinitis toward asthma.

Methods: Using a human pangenomic microarray, we established expression profiles of nasal epithelial cells, collected by brushing of patients belonging to one of four distinct children 2 to 18 years of age groups:

  1. allergic rhinitis to dust mite (AR) isolated (n=12),
  2. AR associated with bronchial hyperreactivity (n=12),
  3. AR associated with asthma (n=14),
  4. control (n=14).
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   6 Years to 17 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

Patients:

  • Patients between 6 and 17 years old
  • Patients with allergic rhinitis

Witness:

  • Patients between 6 and 17 years old
  • Patients without allergic rhinitis and asthma

Exclusion Criteria:

  • Rhino-bronchitis infection dated from less than 15 days
  • Patients younger than 6 or older than 17 years
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00569361


Locations
France
Department of Pediatrics, Nice University Hospital
Nice, France, 06000
Sponsors and Collaborators
Centre Hospitalier Universitaire de Nice
ADPHUN, FRM
Investigators
Principal Investigator: Marc Albertini, Professor Department of Pediatrics of Nice University Hospital
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Département de la Recherche Clinique et de l'Innovation, CHU de Nice
ClinicalTrials.gov Identifier: NCT00569361     History of Changes
Other Study ID Numbers: CIR 2005
First Submitted: December 6, 2007
First Posted: December 7, 2007
Last Update Posted: June 9, 2009
Last Verified: June 2009

Keywords provided by Centre Hospitalier Universitaire de Nice:
allergic rhinitis to dust mite
allergic rhinitis associated with bronchial hyperreactivity
allergic rhinitis associated with asthma

Additional relevant MeSH terms:
Rhinitis
Rhinitis, Allergic
Nose Diseases
Respiratory Tract Diseases
Respiratory Tract Infections
Otorhinolaryngologic Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases