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Continuous Positive Airway Pressure on Tuberculosis Pleural Effusion

This study has been completed.
Information provided by:
Universidade Federal do Rio de Janeiro Identifier:
First received: November 16, 2007
Last updated: NA
Last verified: November 2007
History: No changes posted

Tuberculosis (TB) remains as an important public health problem worldwide. Pleural tuberculosis is the most prevalent form of extrapulmonary presentation in immunocompetent patients.

The volume of effusion in the pleural space of patients with pleural TB may cause complications like restrictive ventilator lung functional disturb and/or pleural thickening. The respiratory physiotherapy can be adjuvant on treatment of pleural effusion tuberculosis throughout of various treatment technique.

The Continuous positive airway pressure (CPAP) is utilized in various pathologic, this improves lung mechanics by recruiting atelectatic alveoli, improving pulmonary compliance, and reducing the work of breathing.

The aim of this study is to determine the effect of CPAP on fluid absorption among patients with pleural effusion due tuberculosis.

Condition Intervention
Pleural Effusion
Behavioral: CPAP

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Effect of Continuous Positive Airway Pressure on Fluid Absorption Among Patients With Pleural Effusion Due to Tuberculosis

Resource links provided by NLM:

Further study details as provided by Universidade Federal do Rio de Janeiro:

Primary Outcome Measures:
  • Evaluate of pleural effusion volume [ Time Frame: one month ]

Enrollment: 20
Study Start Date: March 2005
Study Completion Date: March 2007
Arms Assigned Interventions
Active Comparator: 1 Behavioral: CPAP
Frequency of three times a week, using a positive end expiratory pressure (PEEP) of 10 mmH2O for 30 minutes for four weeks.

Detailed Description:

This randomized and controlled trial compared the reduction of the pleural effusion volume of the group of patients using the anti-TB standard regimen to that using the anti-TB standard regimen AND adjuvant treatment of physical therapy during four weeks.

  • Control group: The patients received rifampicin, isoniazid and pyrazinamide daily(anti-TB standard regimen)
  • Interventional group: The patients received anti-tb standard regime and Continuous Positive Airway Pressure (CPAP) 3 times a week for 30 minutes with positive expiratory end pressure of 10 cmH2O.

Evaluation of the pleural effusion size: a helicoidal thoracic computed tomography (CT) was carried out in all patients enrolled. The valuation was conducted by two radiologists blinded for the treatment used, specifically trained for the purpose of the study.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Confirmed diagnosis of pleural tuberculosis.
  • Patients 18 years of age and older.

Exclusion criteria:

  • Be under previous treatment of respiratory physiotherapy.
  • Irregular use or abandonment of the anti-TB standard regimen.
  • To fail one or more physiotherapy section.
  • To fail one or more radiological evaluation.
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Please refer to this study by its identifier: NCT00560521

Clementino Fraga Filho University Hospital- Federal University of Rio de Janeiro
Rio de Janeiro, Brazil, 21941913
Sponsors and Collaborators
Universidade Federal do Rio de Janeiro
Principal Investigator: Juliana F Oliveira, MD Universidade Federal do Rio de Janeiro
Principal Investigator: Marcus B. Conde, PhD Universidade Federal do Rio de Janeiro
Study Chair: Rosana S. Rodrigues, MD Universidade Federal do Rio de Janeiro
Principal Investigator: Sara L. Menezes, PhD Universidade Federal do Rio de Janeiro
Study Chair: Ana L. Boechat, MD Universidade Federal do Rio de Janeiro
Principal Investigator: Fernanda C. Mello, PhD Universidade Federal do Rio de Janeiro
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00560521     History of Changes
Other Study ID Numbers: Oliveira-1
Study First Received: November 16, 2007
Last Updated: November 16, 2007

Keywords provided by Universidade Federal do Rio de Janeiro:
Pleural effusion

Additional relevant MeSH terms:
Pleural Effusion
Mycobacterium Infections
Actinomycetales Infections
Gram-Positive Bacterial Infections
Bacterial Infections
Pleural Diseases
Respiratory Tract Diseases processed this record on May 25, 2017