Continuous Positive Airway Pressure on Tuberculosis Pleural Effusion
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00560521|
Recruitment Status : Completed
First Posted : November 19, 2007
Last Update Posted : November 19, 2007
Tuberculosis (TB) remains as an important public health problem worldwide. Pleural tuberculosis is the most prevalent form of extrapulmonary presentation in immunocompetent patients.
The volume of effusion in the pleural space of patients with pleural TB may cause complications like restrictive ventilator lung functional disturb and/or pleural thickening. The respiratory physiotherapy can be adjuvant on treatment of pleural effusion tuberculosis throughout of various treatment technique.
The Continuous positive airway pressure (CPAP) is utilized in various pathologic, this improves lung mechanics by recruiting atelectatic alveoli, improving pulmonary compliance, and reducing the work of breathing.
The aim of this study is to determine the effect of CPAP on fluid absorption among patients with pleural effusion due tuberculosis.
|Condition or disease||Intervention/treatment||Phase|
|Tuberculosis Pleural Effusion||Behavioral: CPAP||Not Applicable|
This randomized and controlled trial compared the reduction of the pleural effusion volume of the group of patients using the anti-TB standard regimen to that using the anti-TB standard regimen AND adjuvant treatment of physical therapy during four weeks.
- Control group: The patients received rifampicin, isoniazid and pyrazinamide daily(anti-TB standard regimen)
- Interventional group: The patients received anti-tb standard regime and Continuous Positive Airway Pressure (CPAP) 3 times a week for 30 minutes with positive expiratory end pressure of 10 cmH2O.
Evaluation of the pleural effusion size: a helicoidal thoracic computed tomography (CT) was carried out in all patients enrolled. The valuation was conducted by two radiologists blinded for the treatment used, specifically trained for the purpose of the study.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||20 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Single (Outcomes Assessor)|
|Official Title:||Effect of Continuous Positive Airway Pressure on Fluid Absorption Among Patients With Pleural Effusion Due to Tuberculosis|
|Study Start Date :||March 2005|
|Actual Study Completion Date :||March 2007|
|Active Comparator: 1||
Frequency of three times a week, using a positive end expiratory pressure (PEEP) of 10 mmH2O for 30 minutes for four weeks.
- Evaluate of pleural effusion volume [ Time Frame: one month ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00560521
|Clementino Fraga Filho University Hospital- Federal University of Rio de Janeiro|
|Rio de Janeiro, Brazil, 21941913|
|Principal Investigator:||Juliana F Oliveira, MD||Universidade Federal do Rio de Janeiro|
|Principal Investigator:||Marcus B. Conde, PhD||Universidade Federal do Rio de Janeiro|
|Study Chair:||Rosana S. Rodrigues, MD||Universidade Federal do Rio de Janeiro|
|Principal Investigator:||Sara L. Menezes, PhD||Universidade Federal do Rio de Janeiro|
|Study Chair:||Ana L. Boechat, MD||Universidade Federal do Rio de Janeiro|
|Principal Investigator:||Fernanda C. Mello, PhD||Universidade Federal do Rio de Janeiro|