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A Pilot Study of Functional Optical Coherence Tomography for Ocular Imaging

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00556114
First Posted: November 9, 2007
Last Update Posted: February 10, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Beckman Laser Institute University of California Irvine
Information provided by (Responsible Party):
Beckman Laser Institute and Medical Center, University of California, Irvine
  Purpose
Growing evidence shows that altered blood flow plays a major role in many vision-threatening diseases including glaucoma, diabetic retinopathy, age-related macular degeneration, Central Retinal Vein Occlusion, and Branch Retinal Vein Occlusion. Optical coherence tomography, an established imaging technique use for eye exam in clinical ophthalmology, provides high-resolution cross sectional images of the retina and has increased our ability to understand many eye diseases.

Condition Intervention
Glaucoma Diabetic Retinopathy Age-Related Macular Degeneration Central Retinal Vein Occlusion Branch Retinal Vein Occlusion Device: Optical Coherence Tomography

Study Type: Observational
Study Design: Observational Model: Case-Control
Time Perspective: Prospective
Official Title: A Pilot Study of Functional Optical Coherence Tomography for Ocular Imaging

Resource links provided by NLM:


Further study details as provided by Beckman Laser Institute and Medical Center, University of California, Irvine:

Primary Outcome Measures:
  • Medical exam tool [ Time Frame: 24 hours ]
    Optical Coherence Tomography imaging technique of the retina and ability to diagnose and manage many eye diseases


Enrollment: 23
Study Start Date: January 2007
Study Completion Date: July 2013
Primary Completion Date: July 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Optical Coherence Tomography
Optical Coherence Tomography
Device: Optical Coherence Tomography
Optical Coherence Tomography

Detailed Description:

Optical Coherence Tomography is a non-invasive technique use a broadband light source to illuminate the area of study with light in the near infrared spectrum, then obtains static images of tissue structure from interference signals of the back-reflected light.

Optical Coherence Tomography a non-contact, non-invasive means of documenting both tissue structure and blood flow changes in ocular disease and can provide high resolution cross-sectional images of tissue structure, direct visualization of blood flow in blood vessels of the eye.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Primary care clinic and community sample.
Criteria

Inclusion Criteria:

  • Adult 18 years and older with normal eye, or has been diagnosed with eye disease.

Exclusion Criteria:

  • Less than 18 years of age.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00556114


Locations
United States, California
Beckman Laser Institute, University of California,Irvine
Irvine, California, United States, 02612
Sponsors and Collaborators
University of California, Irvine
Beckman Laser Institute University of California Irvine
Investigators
Principal Investigator: Baruch D Kuppermann,, M.D., Ph.D. Ophthamology, University of California,Irvine
Principal Investigator: Zhongping Chen, Ph,D Beckman Laser Institute University of California Irvine
  More Information

Responsible Party: Beckman Laser Institute and Medical Center, Baruch D. Kuppermann, M.D., Ph.D.,Professor Department of Ophthalmology and Biomedical Engineering, University of California, Irvine
ClinicalTrials.gov Identifier: NCT00556114     History of Changes
Other Study ID Numbers: NIH-LAMMP-2004-3555
First Submitted: November 7, 2007
First Posted: November 9, 2007
Last Update Posted: February 10, 2017
Last Verified: February 2017

Keywords provided by Beckman Laser Institute and Medical Center, University of California, Irvine:
eye exam
Retina

Additional relevant MeSH terms:
Macular Degeneration
Diabetic Retinopathy
Retinal Vein Occlusion
Retinal Degeneration
Retinal Diseases
Eye Diseases
Diabetic Angiopathies
Vascular Diseases
Cardiovascular Diseases
Diabetes Complications
Diabetes Mellitus
Endocrine System Diseases
Venous Thrombosis
Thrombosis
Embolism and Thrombosis