Comparison of Effectiveness and Costs of Post-diagnosis Treatment in Dementia (AD-Euro)
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|ClinicalTrials.gov Identifier: NCT00554047|
Recruitment Status : Completed
First Posted : November 6, 2007
Last Update Posted : January 10, 2011
In the Netherlands a rapidly increasing number of multidisciplinary memory clinics (MMC) currently diagnose 25% of the patients with dementia. Following the diagnostic work-up, MMCs are increasingly involved in post-diagnosis treatment and coordination of care, which probably is very important for patients and caregivers, but also very time consuming and expensive. This study will focus on the important question whether this complex post-diagnosis treatment and care coordination, evaluated both on effectiveness and costs, should be carried out by MMCs (intervention) or by General Practitioners (GPs) (control) as pivot of delivery of health care for these patients.
Objectives: To determine MMCs' effectiveness and cost-effectiveness in post-diagnosis treatment and care-coordination for dementia-patients and their caregivers compared to the post-diagnosis treatment and care coordination by GPs.
Time schedule: 12 months for including patients and their caregivers and 12 months of follow-up.
Annex Study: Specifically for the Health Technology Assessment (HTA) methodology study the main study will be extended with some experimental proxy measurements and alternative measurement approaches.
The objective of this Annex-study is to explore the feasibility and validity of Health Related Quality of Life (HRQL) value measurement in dementia patients. And to study the characteristics of proxy rating in HRQL research in dementia and the suitability and validity of yielding HRQL measurements by proxy assessment. Furthermore to explore the validity, reliability, and feasibility of the EQ5D and EQ6D in dementia research (in patients and in/by proxies); response shift, and alternative (more simple) methods of HRQL measurement and validate the Dutch versions of the QOL-AD and the use of the CarerQol-7D in dementia research.
|Condition or disease||Intervention/treatment||Phase|
|Dementia||Other: Multidisciplinary Memory Clinic Other: General Practitioners||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||220 participants|
|Intervention Model:||Parallel Assignment|
|Primary Purpose:||Health Services Research|
|Official Title:||Effectiveness and Costs of Post-diagnosis Treatment in Dementia Coordinated by Multidisciplinary Memory Clinics in Comparison to Treatment Coordinated by General Practitioners|
|Study Start Date :||December 2007|
|Actual Study Completion Date :||July 2010|
Multidisciplinary Memory Clinic
Other: Multidisciplinary Memory Clinic
Post-diagnosis treatment and coordination of care for patients with dementia and their informal caregivers delivered by Multidisciplinary Memory Clinics (MMCs)
Active Comparator: 2
Other: General Practitioners
Post-diagnosis treatment and coordination of care for patients with dementia and their informal caregivers delivered by general practitioners
- Proxy-rated Health Related Quality of Life of the patient (cpQol-AD) [ Time Frame: at 0, 6 and 12 months ]
- Informal caregivers burden (Sense of competence (SCQ)) [ Time Frame: at 0, 6 and 12 months ]
- Cost utility analysis (EQ 5D) [ Time Frame: at 0, 6 and 12 months ]
- Geriatric Depression Scale (GDS-15) [ Time Frame: at 0, 6 and 12 months ]
- Care-related quality of life of informal caregivers (CarerQol-7D + CarerQol-VAS) [ Time Frame: at 0, 6 and 12 months ]
- Quality of Live AD caregiver (cQoL-AD) [ Time Frame: at 0, 6 and 12 months ]
- Neuro Psychiatric Inventory (NPI-Q) [ Time Frame: at 0, 6 and 12 months ]
- Functional performance patient (IDDD) [ Time Frame: at 0, 6 and 12 months ]
- Patients rated Health Related Quality of Life (pQol-AD) [ Time Frame: at 0, 6 and 12 months ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00554047
|VU Medical Center, Alzheimer Centre|
|Alysis Zorgroep, Rijnstate Hospital, Department of Geriatrics|
|GGZ Oost Brabant, Department of Geriatrics|
|Slingeland Hospital, Department of Geriatrics|
|Hospital Gelderse Vallei, Department of Geriatrics|
|Catharina hospital, Department of Geriatrics|
|Elkerliek Hospital, Department of Geriatrics|
|University Hospital Maastricht, Alzheimer Centre|
|University Medical Centre St Radboud, Alzheimer Centre|
|Principal Investigator:||Prof. Dr. M. Olde Rikkert, MD PhD||University Medical Centre St Radboud, Nijmegen|