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PERG and mfPERG in Band Atrophy

This study has been completed.
Fundação de Amparo à Pesquisa do Estado de São Paulo
Information provided by:
University of Sao Paulo Identifier:
First received: November 5, 2007
Last updated: August 4, 2011
Last verified: November 2007
The study is designed to evaluate the ability of pattern electroretinogram (PERG) and multifocal pattern electroretinogram (mfPERG) to measure and identify the pattern of band atrophy of the optic nerve in patients with long standing chiasmal lesions. The hypothesis is that these electrophysiological tests were able to identify this such pattern. The idea is to investigate the ability of the these electrophysiological technics in detecting the neural loss from chiasmal compression and to evaluate the ability of PERG and mfPERG parameters to differentiate between eyes with band atrophy of the optic nerve and healthy eyes.

Condition Intervention
Band Atrophy Device: Pattern electroretinogram

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Pattern Electroretinogram and Multifocal Pattern Electroretinogram For the Detection of Neural Loss in Patients With Permanent Temporal Visual Field Defect From Chiasmal Compression

Further study details as provided by University of Sao Paulo:

Estimated Enrollment: 30
Study Start Date: August 2006
Study Completion Date: July 2009
Primary Completion Date: July 2008 (Final data collection date for primary outcome measure)
Intervention Details:
    Device: Pattern electroretinogram
    Full field and hemifield (nasal and temporal) stimulation transient pattern electroretinogram (PERG) were recorded both in patients and controls.

Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with band atrophy from chismal compression and controls

Inclusion Criteria:

  1. Visual acuity better than 20/30
  2. Refractive error less 5 spherical diopter and 3 cylinder diopter
  3. Temporal field defect

Exclusion Criteria:

  1. Presence of glaucoma and optic nerve anomalies
  2. Anormal nasal field
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Please refer to this study by its identifier: NCT00553761

Universidade de São Paulo
São Paulo, Brazil, 05403-000
Sponsors and Collaborators
University of Sao Paulo
Fundação de Amparo à Pesquisa do Estado de São Paulo
Study Chair: Mário Luiz R Monteiro, PhD University of Sao Paulo
  More Information

Additional Information:
Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Mario Luiz Ribeiro Monteiro/University of Sao Paulo, University of Sao Paulo Identifier: NCT00553761     History of Changes
Other Study ID Numbers: 654/06
FAPESP 06/61549-6; 07/54142-0)
Study First Received: November 5, 2007
Last Updated: August 4, 2011

Keywords provided by University of Sao Paulo:
Band atrophy
Pattern electroretinogram
Chiasmal compression
Neural loss
Electrophysiological tests

Additional relevant MeSH terms:
Pathological Conditions, Anatomical processed this record on June 22, 2017