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Simvastatin Reduces Adiponectin Levels and Insulin Sensitivity

This study has been completed.
Information provided by:
Gachon University Gil Medical Center Identifier:
First received: October 17, 2007
Last updated: NA
Last verified: October 2007
History: No changes posted
We hypothesized simvastatin may reduce adiponectin levels and insulin sensitivity in overweight hypercholesterolemic patients.


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Phase 4 Study of Simvastatin That Affects Insulin Sensitivity

Resource links provided by NLM:

Further study details as provided by Gachon University Gil Medical Center:

Primary Outcome Measures:
  • simvastatin may reduce adiponectin levels and insulin sensitivity in overweight hypercholesterolemic patients

Study Start Date: January 2004

Ages Eligible for Study:   25 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Study Population
overweight hypercholesterolemic patients

Inclusion Criteria:

  • Low-density lipoprotein cholesterol levels more than 100 and body mass index more than 23.0

Exclusion Criteria:

  • Patients with overt liver disease
  • Chronic renal failure
  • Hypothyroidism, myopathy
  • Uncontrolled diabetes
  • Severe hypertension, stroke
  • Acute coronary events
  • Coronary revascularization within the preceding 3 months, or
  • Alcohol abuse.
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Please refer to this study by its identifier: NCT00546182

Korea, Republic of
Gil Medical Center, Gachon University
Incheon, Korea, Republic of, 405760
Sponsors and Collaborators
Gachon University Gil Medical Center
Principal Investigator: Kwang K Koh, MD,PhD Gachon University Gil Medical Center
  More Information

Publications: Identifier: NCT00546182     History of Changes
Other Study ID Numbers: GMC-200405
Study First Received: October 17, 2007
Last Updated: October 17, 2007

Keywords provided by Gachon University Gil Medical Center:
Lipophilic statins
Insulin resistance
hypercholesterolemic patients

Additional relevant MeSH terms:
Insulin Resistance
Lipid Metabolism Disorders
Metabolic Diseases
Glucose Metabolism Disorders
Hypoglycemic Agents
Physiological Effects of Drugs
Anticholesteremic Agents
Hypolipidemic Agents
Molecular Mechanisms of Pharmacological Action
Lipid Regulating Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Enzyme Inhibitors processed this record on May 23, 2017