Effects of a Complex Cognitive Training in Mild Cognitive Impairment and Mild Alzheimer's Disease
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|ClinicalTrials.gov Identifier: NCT00544856|
Recruitment Status : Completed
First Posted : October 16, 2007
Last Update Posted : January 29, 2009
A recent meta-analysis that included over 29.000 individuals found that the odds ratio (OR) of individuals with high brain reserve compared to low was 0.54 (p < 0.0001), a risk decrease of 46%. Among the factors that influence cognitive reserve, mentally stimulating activities was the most robust factor after controlling for education, age, occupation and other potential confounds. The brain reserve effect was sustained over a median longitudinal follow-up of 7 years. It would be interesting to detect whether a complex cognitive training could show similar effects on the cognitive abilities of patients with mild Alzheimer's disease (AD) and mild cognitive impairment (MCI) as it has been reported in previous studies based on mentally stimulating activities analysis.
The hypothesis is that a complex cognitive training alters the neural networks in both subject groups and this alteration is associated with improvement or stabilization of cognitive and non-cognitive function.
The investigator will perform a complex cognitive training program. Twenty patients with mild AD and twenty four patients with MCI will be recruited in this study. The patients will be randomised in control- and treatment groups.Additionally indirect effects on non-cognitive functions will be evaluated in caregivers of the patients.
The investigators expect that the cognitive and non-cognitive abilities will be changed during the cognitive training. The investigators also expect differences between treatment and control groups.
|Condition or disease||Intervention/treatment||Phase|
|Alzheimer's Disease Cognitive Impairment||Behavioral: complex cognitive training||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||39 participants|
|Intervention Model:||Crossover Assignment|
|Study Start Date :||October 2007|
|Actual Primary Completion Date :||October 2008|
|Actual Study Completion Date :||October 2008|
|Behavioral: complex cognitive training|
|Placebo Comparator: 2||Behavioral: complex cognitive training|
- cognition: MMSE, ADAS-cog. [ Time Frame: month 0, 6, 12 ]
- quality of life [ Time Frame: month 0, 6, 12 ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00544856
|Study Chair:||Harald Hampel, MD||Department of Psychiatry, Ludwig-Maximilian University, Munich Germany|