A Long-Term Examination of Asthma From Childhood Through Adolescence

This study is ongoing, but not recruiting participants.
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Professor S Hasan Arshad, Isle of Wight NHS Trust
ClinicalTrials.gov Identifier:
First received: October 9, 2007
Last updated: October 6, 2015
Last verified: October 2015
Asthma is a common disease that is often diagnosed in childhood. In some teenagers, asthma symptoms disappear and treatment can be stopped; however, for some of these people, asthma symptoms return in adulthood. This study will examine data collected over the lifetime of 18-year olds to identify factors that may increase a person's chance of having recurrent asthma as an adult.

Dermatitis, Atopic

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Epidemiology of Asthma and Allergic Disease: Risk and Prognosis in a Cohort From Birth to Adolescence

Resource links provided by NLM:

Further study details as provided by Isle of Wight NHS Trust:

Primary Outcome Measures:
  • Identifying factors that may increase a person's chance of having recurrent asthma as an adult [ Time Frame: Measured throughout the participant's lifetime ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA
Whole blood, serum, saliva, urine

Estimated Enrollment: 1200
Study Start Date: September 2007
Estimated Study Completion Date: December 2016
Primary Completion Date: May 2012 (Final data collection date for primary outcome measure)
Detailed Description:

Asthma is a serious, long-term illness that affects around 15% of children in the United States. During adolescence, up to 50% of teenagers stop experiencing symptoms and are able to discontinue treatment. However, asthma symptoms often reoccur in adulthood for many of these people. It is not known exactly what causes this recurrence, but potential risk factors may include obesity, elevated serum leptin levels, early onset of puberty, exposure to pollutants, parental smoking habits, and lack of breastfeeding. Additionally, it is not known why childhood asthma is initially more prevalent in boys, but during adolescence it becomes more prevalent in girls. Beginning in 1989, a group of children born on the Isle of Wight in the United Kingdom has been followed by study researchers to provide long-term information on asthma. These children have been periodically evaluated over the years and are now 18 years old. The purpose of this study is to analyze participants' data collected over a span of 18 years to identify factors that may increase a person's risk of experiencing persistent or recurrent asthma in adulthood.

At previous study visits that occurred when participants were 1, 2, 4, and 10 years old, information on the following was collected: asthma and other allergic diseases, family history of asthma, and early life risk factors, including breastfeeding and tobacco smoke exposure. A blood sample was collected at participants' 10-year study visit. For this current study, all 18-year-old participants will return for a study visit. Participants will complete questionnaires on asthma and allergy symptoms and environmental exposures, including tobacco smoke and pollution. Blood collection, an allergy skin prick test, lung function testing, and a bronchial challenge test to assess airway function will occur. Select participants will also have a sputum sample collected.


Ages Eligible for Study:   17 Years to 19 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
The study population consists of around 1500 unselected subjects (now age 18) who were recruited at birth. This is a homogenous population with 99% being Caucasians.

Inclusion Criteria:

  • Born on the Isle of Wight in the United Kingdom between January 1, 1989 and February 28, 1990

Exclusion criteria:

  • Refused consent
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00541255

United Kingdom
The David Hide Asthma and Allergy Research Centre
Newport, Isle of Wight, United Kingdom, PO305TG
Sponsors and Collaborators
Isle of Wight NHS Trust
National Heart, Lung, and Blood Institute (NHLBI)
Principal Investigator: Syed Arshad, MD University of Southampton, United Kingdom
  More Information

Additional Information:
Responsible Party: Professor S Hasan Arshad, Chair in Allergy and Clinical Immunology, University of Southampton and Hon. Consultant Physician, University Hospital Southampton Director, The David Hide Asthma and Allergy Research Centre, Isle of Wight NHS Trust
ClinicalTrials.gov Identifier: NCT00541255     History of Changes
Other Study ID Numbers: 1408  R01HL082925  1R01HL082925-01A2 
Study First Received: October 9, 2007
Last Updated: October 6, 2015
Health Authority: United States: Federal Government
United Kingdom: Research Ethics Committee

Keywords provided by Isle of Wight NHS Trust:
Bronchial Asthma
Food Allergy
Bronchial Hyperresponsiveness

Additional relevant MeSH terms:
Dermatitis, Atopic
Bronchial Diseases
Genetic Diseases, Inborn
Hypersensitivity, Immediate
Immune System Diseases
Lung Diseases
Lung Diseases, Obstructive
Respiratory Hypersensitivity
Respiratory Tract Diseases
Skin Diseases
Skin Diseases, Eczematous
Skin Diseases, Genetic

ClinicalTrials.gov processed this record on May 24, 2016