Impact of Weight Loss Following Bariatric Surgery on Pulmonary Function in Patients With Morbid Obesity

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00532896
Recruitment Status : Completed
First Posted : September 21, 2007
Last Update Posted : February 22, 2012
Information provided by (Responsible Party):
Louis-Philippe Boulet, Laval University

Brief Summary:

Increase in body mass index (BMI)is associated with a decrease in expiratory flows.Obesity is also associated with an increased prevalence of asthma.Consequences of obesity on respiratory function and on bronchial responsiveness are still to be documented.

This study aims to evaluate, before and after surgery, the impact of a bariatric surgery (biliopancreatic diversion with duodenal switch)on respiratory function in patients with morbid obesity .

Our hypothesis is that weight loss following bariatric surgery will induce significant improvements in pulmonary function and airway responsiveness, and, as a consequence, a reduction in respiratory symptoms,these changes being correlated with a reduction in systemic markers of inflammation. Maintenance of weight loss after one year will permit the persistence of these improvements

Condition or disease
Bariatric Surgery Obesity Respiratory Diseases

Detailed Description:

Patients will be evaluated before the surgery (time zero), 6 months and one year after their surgery. A control group of patients on a waiting list for bariatric surgery will be evaluated at time zero and after 6 months and one year.

At each visit,patients will:

  • fill a standardized respiratory questionnaire and a questionnaire on sleep apnea; questionnaires on asthma control will be completed by patients with asthma.
  • have a spirometry, pulmonary volumes measures by body plethysmography and methacholine inhalation test with evaluation of symptoms perception.
  • an induced sputum will be performed.
  • A blood sample will be drawn to evaluate inflammation and measure C-reactive protein concentration in plasma.
  • An allergy skin prick test will be done at time zero.

Study Type : Observational
Actual Enrollment : 60 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Impact of Weight Loss Following Bariatric Surgery on Pulmonary Function in Patients With Morbid Obesity
Study Start Date : April 2006
Primary Completion Date : January 2011
Study Completion Date : May 2011

Resource links provided by the National Library of Medicine

U.S. FDA Resources

bariatric surgery
patients with morbid obesity undergoing a bariatric surgery
No bariatric surgery
patients with morbid obesity on a waiting list for a bariatric surgery but who will have their surgery in more than one year.

Biospecimen Retention:   Samples Without DNA
serum plasma

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Subjects on the waiting list for bariatric surgery at Laval Hospital will be offered to participate to the study.

Inclusion Criteria:

  • Body mass index >or= 35 kg/m2
  • Non-smokers or ex-smokers (<10 packs-year)

Exclusion Criteria:

  • Previous bariatric surgery
  • previous vagotomy
  • no compliance to visits
  • subjects unable to provide an informed consent or to understand the questions included in questionnaires
  • Patients with cardiac pacemaker
  • hemodynamically significant valvulopathy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00532896

Canada, Quebec
Centre de Recherche, Hôpital Laval
Québec, Quebec, Canada, G1V 4G5
Sponsors and Collaborators
Laval University
Principal Investigator: Louis-Philippe Boulet, MD Hôpital Laval

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Louis-Philippe Boulet, MD, FRCPC, FCCP, Laval University Identifier: NCT00532896     History of Changes
Other Study ID Numbers: HL-Ch-BAR-Pneu-20086
First Posted: September 21, 2007    Key Record Dates
Last Update Posted: February 22, 2012
Last Verified: February 2012

Additional relevant MeSH terms:
Weight Loss
Obesity, Morbid
Respiration Disorders
Respiratory Tract Diseases
Nutrition Disorders
Body Weight
Signs and Symptoms
Body Weight Changes