Effect of Vardenafil on Blood Pressure in Patients With Erectile Dysfunction Who Received Concomitant Doxazosin GITS
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Mean maximal change of the standing systolic blood pressure (SBP) from half hour prior to till six hour after administration of the drug (baseline) with vardenafil administration versus placebo [ Time Frame: From half hour prior to till six hour after administration of the drug (baseline) ]
Secondary Outcome Measures
Mean maximal post-baseline change of the standing and supine diastolic blood pressure (DBP) [ Time Frame: From half hour prior to till six hour after administration of the drug (baseline) ]
Mean maximal post-baseline change supine SBP, and (3) the pattern of changes of the SBP and DBP from half hour prior to till six hours after administration of the drug [ Time Frame: From half hour prior to till six hour after administration of the drug (baseline) ]
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Ages Eligible for Study:
50 Years to 80 Years (Adult, Senior)
Sexes Eligible for Study:
Age between 50 to 80 years old
Clinically diagnosed to have lower urinary tract symptoms secondary to BPH:
Suffered from lower urinary tract symptoms with International Prostate Symptom Score (IPSS) >=8
Detectable prostatic enlargement determined by Digital Rectum Examination (DRE)
Urinary flow between 5 to 15ml/second in a total void volume >=150mL
Currently on regular doxazosin GITS once-daily for at least 4 weeks without clinically significant side effects
Complaints of erectile dysfunction with Erectile Function domain (EF) of the International Index of Erectile Function (IIEF) score <= 21