Filgrastim-Mobilized Peripheral Blood Stem Cells for Allogeneic Transplantation With Unrelated Donors
Peripheral blood stem cells (PBSCs) collected following stimulation with filgrastim are commonly used for autologous hematopoietic transplants. PBSCs are also now being used for some syngeneic and allogeneic hematopoietic transplants involving HLA-matched sibling donors. However, many issues remain unanswered about the use of PBSCs for allogeneic transplants and the effects of filgrastim on healthy individuals. The purpose of this study is to determine the effectiveness of filgrastim stimulated PBSCs in hematopoietic cell transplants involving unrelated donors and to determine the effects of this donation process on unrelated stem cell donors.
|Study Design:||Time Perspective: Prospective|
|Official Title:||Filgrastim-Mobilized Peripheral Blood Stem Cells for Allogeneic Transplantation With Unrelated Donors|
|Study Start Date:||August 2005|
|Estimated Study Completion Date:||November 2007|
This study establishes and evaluates a system to supply peripheral blood stem cell (PBSC)products for use in unrelated donor hematopoietic stem cell (HSC) transplantation. The protocol describes processes for donor identification, education and evaluation. Procedures for administration and monitoring of the stem cell mobilizing agent filgrastim are included. The study also describes procedures for the collection of PBSC products by leukapheresis and includes provisions for indefinite donor follow-up.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00511550
|United States, California|
|University of California San Francisco Medical Center|
|San Francisco, California, United States, 94143-0324|
|Principal Investigator:||Thomas G. Martin, M.D.||University of California, San Francisco|
|Study Director:||John Miller, M.D.,Ph.D.||National Marrow Donor Program|