Effects of HIV and Hepatitis C Virus on the Brain
|ClinicalTrials.gov Identifier: NCT00494936|
Recruitment Status : Completed
First Posted : July 2, 2007
Last Update Posted : May 25, 2015
|Condition or disease|
|HIV Infections Hepatitis C|
Hepatitis C is a liver disease that is caused by the hepatitis C virus (HCV). It can be successfully treated with 6 to 12 months of medication in both HIV infected and HIV uninfected people. Among HIV infected people, HCV infection is a common co-morbidity, and is more serious when it occurs in this population than others because it leads to liver damage more quickly. HIV is known to cause neurological deficits, and studies suggest that HCV may do so, as well. Knowledge about how to treat these deficits, however, is limited. More information about the nature of the neurological problems and their causes is needed to develop effective treatments. This study will determine the effects that HIV and HCV have on thinking abilities, such as memory, attention, and problem-solving, and whether the viruses affect brain chemistry.
Participants in this 4-year, observational study will undergo a series of tests and interviews. Participants may choose to complete all procedures over 2 days or three appointments. Procedures will include a 20-minute medical interview, a 4-hour neuropsychological evaluation, a 5-minute functional ability questionnaire, blood and urine collection (approximately 15 minutes), and a 1-hour magnetic resonance imaging (MRI) test of the head. The neuropsychological evaluation will test participants' memory, concentration, reasoning, and speed of thinking. All procedures will be completed over approximately 6 hours.
|Study Type :||Observational|
|Actual Enrollment :||78 participants|
|Official Title:||HIV/HCV: Neuropsychiatric and Neurophysiological Features|
|Study Start Date :||May 2006|
|Actual Primary Completion Date :||July 2009|
|Actual Study Completion Date :||July 2009|
HIV and HCV coinfected
HIV and HCV coinfected with HCV RNA less than 600 copies
HCV monoinfected with HCV viremia
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00494936
|United States, New York|
|Mount Sinai School of Medicine|
|New York, New York, United States, 10029-6574|
|Principal Investigator:||Elizabeth Ryan, PhD||Icahn School of Medicine at Mount Sinai|