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Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00484250
First Posted: June 8, 2007
Last Update Posted: June 11, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Mashhad University of Medical Sciences
  Purpose
Oral lichen planus (OLP) is a chronic inflammatory disorder which causes local irritation,discomfort and subsequent poor dentition and discomfort in eating . Various treatments have been suggested for OLP but their results are unsatisfactory .Despite the fact that steroids have been the main therapeutic choice for many years,some researches have been done regarding the efficacy of other medication such as metronidazole and doxycycline.The purpose of this study is to determine whether metronidazole and doxycycline are effective in the treatment of oral lichen planus and to compare their efficacy with each other.

Condition Intervention Phase
Oral Lichen Planus Drug: metronidazole,doxycycline Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment

Resource links provided by NLM:


Further study details as provided by Mashhad University of Medical Sciences:

Enrollment: 20
Study Start Date: September 2005
Study Completion Date: May 2006
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • a biopsy-proven untreated OLP of every type with no symptom.

Exclusion Criteria:

  • pregnancy, presence of dysplasia in lesions,unilateral lesion suspected lichenoid reaction,history of drinking alcohol in at least 1 month prior to the study, smoking, systemic disease, use of systemic medications and hypersensitivity to the metronidazole and doxycycline.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00484250


Locations
Iran, Islamic Republic of
Mashhad University Of Medical Sciences(Dentistry School)
Mashhad, Khorasan, Iran, Islamic Republic of, 91375345
Sponsors and Collaborators
Mashhad University of Medical Sciences
Investigators
Study Chair: Arash Mansourian, DDS,MS Tehran University of Medical Sciences
Study Director: Majid Sanatkhani, DDS,MS Mashhad University of Medical Sciences
Principal Investigator: Fatemeh Momen Heravi Tehran University of Medical Sciences
  More Information

Additional Information:
ClinicalTrials.gov Identifier: NCT00484250     History of Changes
Other Study ID Numbers: 240
First Submitted: June 7, 2007
First Posted: June 8, 2007
Last Update Posted: June 11, 2007
Last Verified: June 2007

Keywords provided by Mashhad University of Medical Sciences:
Oral Lichen Planus
Metronidazole
Doxycycline

Additional relevant MeSH terms:
Lichen Planus
Lichen Planus, Oral
Lichenoid Eruptions
Skin Diseases, Papulosquamous
Skin Diseases
Mouth Diseases
Stomatognathic Diseases
Metronidazole
Doxycycline
Anti-Infective Agents
Antiprotozoal Agents
Antiparasitic Agents
Anti-Bacterial Agents
Antimalarials