Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00484250
Recruitment Status : Completed
First Posted : June 8, 2007
Last Update Posted : June 11, 2007
Information provided by:
Mashhad University of Medical Sciences

Brief Summary:
Oral lichen planus (OLP) is a chronic inflammatory disorder which causes local irritation,discomfort and subsequent poor dentition and discomfort in eating . Various treatments have been suggested for OLP but their results are unsatisfactory .Despite the fact that steroids have been the main therapeutic choice for many years,some researches have been done regarding the efficacy of other medication such as metronidazole and doxycycline.The purpose of this study is to determine whether metronidazole and doxycycline are effective in the treatment of oral lichen planus and to compare their efficacy with each other.

Condition or disease Intervention/treatment Phase
Oral Lichen Planus Drug: metronidazole,doxycycline Phase 2

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 20 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Study Start Date : September 2005
Actual Study Completion Date : May 2006

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • a biopsy-proven untreated OLP of every type with no symptom.

Exclusion Criteria:

  • pregnancy, presence of dysplasia in lesions,unilateral lesion suspected lichenoid reaction,history of drinking alcohol in at least 1 month prior to the study, smoking, systemic disease, use of systemic medications and hypersensitivity to the metronidazole and doxycycline.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00484250

Iran, Islamic Republic of
Mashhad University Of Medical Sciences(Dentistry School)
Mashhad, Khorasan, Iran, Islamic Republic of, 91375345
Sponsors and Collaborators
Mashhad University of Medical Sciences
Study Chair: Arash Mansourian, DDS,MS Tehran University of Medical Sciences
Study Director: Majid Sanatkhani, DDS,MS Mashhad University of Medical Sciences
Principal Investigator: Fatemeh Momen Heravi Tehran University of Medical Sciences

Additional Information: Identifier: NCT00484250     History of Changes
Other Study ID Numbers: 240
First Posted: June 8, 2007    Key Record Dates
Last Update Posted: June 11, 2007
Last Verified: June 2007

Keywords provided by Mashhad University of Medical Sciences:
Oral Lichen Planus

Additional relevant MeSH terms:
Lichen Planus
Lichen Planus, Oral
Lichenoid Eruptions
Skin Diseases, Papulosquamous
Skin Diseases
Mouth Diseases
Stomatognathic Diseases
Anti-Infective Agents
Antiprotozoal Agents
Antiparasitic Agents
Anti-Bacterial Agents