In Vitro Maturation of Immature Oocytes

This study has been completed.
Information provided by:
Sheba Medical Center Identifier:
First received: May 29, 2007
Last updated: December 16, 2008
Last verified: December 2008

The aim of this study is to aspirate immature oocytes from antral follicles and mature the oocytes in vitro. These mature oocytes will serve for fertilization and the creation of embryos which will be replace in the uterus as performed during normal IVF.We will record the efficacy and safety of this procedure.

Condition Intervention
Polycystic Ovary Syndrome
Ovarian Hyperstimulation Syndrome
Procedure: In Vitro Maturation of immature oocytes

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment

Further study details as provided by Sheba Medical Center:


Ages Eligible for Study:   20 Years to 45 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Women with PCOS
  • Women with previous Hyperstimulation or with risk of developing hyperstimulation during IVF Treatment
  • Women diagnosed with cancer who are interested in fertility preservation
  • Women with repeated IVF failure

Exclusion Criteria:

  • Severe cases of endometriosis
  • Large myomas
  • Hydrosalpinxs Technical problem with previous oocytes pick-up
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00480337

IVF Unit, Shea Medical Center, Tel-Hashomer
Ramat-Gan, Israel, 52621
Sponsors and Collaborators
Sheba Medical Center
Principal Investigator: Ariel Hourvitz IVF Unit, Sheba Medical Center
  More Information

No publications provided Identifier: NCT00480337     History of Changes
Other Study ID Numbers: SHEBA-06-4317-AH-CTIL
Study First Received: May 29, 2007
Last Updated: December 16, 2008
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration

Keywords provided by Sheba Medical Center:
Fertility Preservation
Repeated IVF Failure
S/P Hyperstimulation

Additional relevant MeSH terms:
Ovarian Hyperstimulation Syndrome
Polycystic Ovary Syndrome
Adnexal Diseases
Endocrine System Diseases
Genital Diseases, Female
Gonadal Disorders
Ovarian Cysts
Ovarian Diseases
Pathologic Processes processed this record on October 13, 2015