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Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients

This study has been completed.
Information provided by:
Universita di Verona Identifier:
First received: May 23, 2007
Last updated: NA
Last verified: May 2007
History: No changes posted
In patients with chronic heart failure (CHF)due to dilated cardiomyopathy diastolic dysfunction occurs frequently and is related to a poor outcome. We have previously shown that parameters of diastolic function significantly correlate with uric acid levels, a marker of impaired oxidative metabolism. We aimed to determine whether inhibition of xanthine oxidase with allopurinol might affect diastolic function in patients with CHF.

Condition Intervention Phase
Chronic Heart Failure
Drug: allopurinol
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients

Resource links provided by NLM:

Further study details as provided by Universita di Verona:

Primary Outcome Measures:
  • diastolic function uric acid levels BNP [ Time Frame: three months ]


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • chronic heart failure;
  • left ventricular systolic dysfunction (ejection fraction <45%)
  • stable clinical conditions in the previous three months
  • optimal medical therapy for CHF
  • normal sinus rhythm
  • written informed consent
  • age >18 years

Exclusion Criteria:

  • renal failure (s-creatinine >2.5 mg/dl)
  • already on allopurinol
  • malignancies
  • chronic inflammatory diseases
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Please refer to this study by its identifier: NCT00477789

Division of Cardiology, University Hospital of Verona
Verona, Italy, 37129
Sponsors and Collaborators
Universita di Verona
Principal Investigator: Mariantonietta Cicoira, MD, PhD Division of Cardiology, University of Verona, Italy
  More Information Identifier: NCT00477789     History of Changes
Other Study ID Numbers: 802
Study First Received: May 23, 2007
Last Updated: May 23, 2007

Keywords provided by Universita di Verona:
chronic heart failure
diastolic dysfunction
uric acid

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases
Molecular Mechanisms of Pharmacological Action
Enzyme Inhibitors
Gout Suppressants
Antirheumatic Agents
Free Radical Scavengers
Protective Agents
Physiological Effects of Drugs processed this record on May 25, 2017