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MR, Myocardial Infarct and Heart Failure (KoMPiS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00465868
Recruitment Status : Completed
First Posted : April 25, 2007
Last Update Posted : July 28, 2015
Helse Vest
Norwegian Foundation for Health and Rehabilitation
Norwegian Heart and Lung Patient Organization
Sparebank 1 SR-Bank Gavefond
Amersham Health
Information provided by (Responsible Party):
Helse Stavanger HF

Brief Summary:
KoMPiS is a contrast aided cardiac magnetic resonance study of microvascular obstruction and left ventricular remodelling following acute revascularised anterior myocardial infarction. The study will monitor the included patients for 12 months following the acute myocardial infarct and collect data from MR scans and blood samples. The study is designed to demonstrate that obstruction of blood flow in the peripheral (small) vessels of the cardiac muscle is an important factor in the post-MI development of left ventricle dysfunction that occurs in many patients, despite of a successful re-opening of the occluded coronary artery that caused the MI.

Condition or disease Intervention/treatment
Heart Failure, Congestive Procedure: PCI (percutaneous coronary intervention)

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Study Type : Observational
Actual Enrollment : 44 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Magnetic Resonance Imaging, Myocardial Infarction and Development of Heart Failure.
Study Start Date : December 2004
Actual Primary Completion Date : May 2007
Actual Study Completion Date : May 2007

Resource links provided by the National Library of Medicine

Intervention Details:
  • Procedure: PCI (percutaneous coronary intervention)
    Outcome of PCI following AMI

Biospecimen Retention:   Samples Without DNA
collagen markers, inflammatory markers and heart failure markers

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients admited with AMi and rescue PCI.

Inclusion Criteria:

  • Men or women > 18 years of age, non-child bearing potential
  • First time acute myocardial infarction, as determined by evidence of transmural ischemia in the ECG and a rise in cardiac-Troponin-T (TNT) > 0,1 (μg/l), followed by
  • A successful acute PCI of a single vessel disease with a proximal/mid left anterior descent artery (LAD), circumflex artery (RCX) or right coronary artery (RCA) lesion (the index PCI).

Exclusion Criteria:

  • Extensive cardiopulmonary resuscitation.
  • Haemodynamically unstable patients, unable to leave the coronary care unit for the CMR examination.
  • Use of fibrinolytics immediately prior to the index PCI.
  • Significant primary valve disease,
  • Autoimmune disease causing an increase in collagen turnover
  • Active cancer disease
  • Need for immunosuppressive treatment,
  • Significantly reduced liver function
  • Contraindications for performing a cardiac MRI-scan (claustrophobia, and implanted ferromagnetic devices, known allergic reactions to Omniscan™).
  • Inability to understand the consent form or cooperate during the 1 year follow up.
  • Comorbidity with poor prognosis.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00465868

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Stavanger University Hospital
Stavanger, Norway, NO-4011
Sponsors and Collaborators
Helse Stavanger HF
Helse Vest
Norwegian Foundation for Health and Rehabilitation
Norwegian Heart and Lung Patient Organization
Sparebank 1 SR-Bank Gavefond
Amersham Health
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Study Chair: Kenneth Dickstein, PhD Universiy of Bergen, Norway
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Helse Stavanger HF Identifier: NCT00465868    
Other Study ID Numbers: StaHF461301
First Posted: April 25, 2007    Key Record Dates
Last Update Posted: July 28, 2015
Last Verified: June 2008
Keywords provided by Helse Stavanger HF:
Acute Myocardial Infarction
Coronary Revascularization
Microvascular Obstruction
Cardiac MR
Collagen Turnover
Heart failure, post-mi
Additional relevant MeSH terms:
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Heart Failure
Heart Diseases
Cardiovascular Diseases